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tubulin tyrosine ligase like 5

Summary

Gene Symbol

TTLL5

Organism

Homo sapiens (human)

External Links

NCBI Gene

23093

PubChem

23093

Alliance of Genome Resources

HGNC:19963

JoGo

TTLL5

TogoVar

TTLL5

Annotation

Keyword

ATP-binding
Alternative splicing
Cilium
Cone-rod dystrophy
Cytoskeleton
Disease variant
Ligase
Magnesium
Metal-binding
Microtubule
Nucleus
Proteomics identification
Reference proteome
Transcription

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6EMB2	SRC1 and TIF2-associated modulatory protein Tubulin--tyrosine ligase-like protein 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
microtubule cytoskeleton organization
sperm axoneme assembly	IBA
protein modification process	IEA
retina development in camera-type eye	IMP	24791901

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process

macromolecule modification [inference]

protein modification process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

microtubule bundle formation [inference]

axoneme assembly [inference]

sperm axoneme assembly

cellular process involved in reproduction in multicellular organism [inference]

sperm axoneme assembly

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

microtubule bundle formation [inference]

axoneme assembly [inference]

sperm axoneme assembly

cellular component assembly [inference]

axoneme assembly [inference]

sperm axoneme assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

sperm axoneme assembly

cellular process involved in reproduction in multicellular organism [inference]

sperm axoneme assembly

developmental process [inference]

developmental process involved in reproduction [inference]

sperm axoneme assembly

anatomical structure development [inference]

retina development in camera-type eye

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
centrosome	IDA	21399614
cytosol	TAS
cytosol	IDA
microtubule	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

cytosol

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA
tubulin binding	IBA
metal ion binding	IEA
tubulin-glutamic acid ligase activity	ISS
tubulin-glutamic acid ligase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

acid-amino acid ligase activity [inference]

protein-glutamic acid ligase activity [inference]

catalytic activity, acting on a protein [inference]

protein-glutamic acid ligase activity [inference]

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111025	cone-rod dystrophy 19	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements