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structural maintenance of chromosomes 5

Summary

Gene Symbol

SMC5

Organism

Homo sapiens (human)

External Links

NCBI Gene

23137

PubChem

23137

Alliance of Genome Resources

HGNC:20465

JoGo

SMC5

TogoVar

SMC5

Annotation

Keyword

ATP-binding
Coiled coil
DNA recombination
DNA repair
Disease variant
Mitosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Telomere
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IY18

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
telomere maintenance via recombination	IMP	17589526
double-strand break repair via homologous recombination	NAS	16810316
double-strand break repair via homologous recombination	IMP	16810316
double-strand break repair via homologous recombination	IBA
double-strand break repair via nonhomologous end joining	IMP	16810316

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

cellular senescence

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

cellular process [inference]

cell cycle process [inference]

chromosome segregation

cell cycle phase transition [inference]

mitotic cell cycle phase transition

mitotic cell cycle process [inference]

mitotic cell cycle phase transition

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

cellular senescence

cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

chromosome condensation

telomere organization [inference]

telomere maintenance [inference]

telomere maintenance via recombination

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin looping

multicellular organismal process [inference]

stem cell population maintenance

developmental process [inference]

maintenance of cell number [inference]

stem cell population maintenance

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

negative regulation by host of viral process [inference]

negative regulation by host of viral genome replication

modulation by host of viral genome replication [inference]

negative regulation by host of viral genome replication

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

regulation of macromolecule metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of chromosome segregation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of chromosome segregation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of chromosome organization [inference]

regulation of sister chromatid cohesion [inference]

regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of telomere maintenance

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of sister chromatid cohesion [inference]

regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

regulation of chromosome segregation [inference]

positive regulation of chromosome segregation

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of chromosome segregation

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion

positive regulation of chromosome segregation

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
chromosome, centromeric region	IEA
chromosome, telomeric region	NAS	17589526
chromosome, telomeric region	IDA	17589526
sex chromosome	ISS
nucleus	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

SUMO ligase complex [inference]

Smc5-Smc6 complex

cellular anatomical entity [inference]

nuclear body [inference]

cell junction

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

sex chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

sex chromosome

site of DNA damage [inference]

site of double-strand break

chromosomal region [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
DNA secondary structure binding	IDA	28095508
single-stranded DNA binding	IBA
protein binding	IPI	11408570 15601840 18086888 25931565 26496610 28514442 32296183 32389690 33961781 36373674
ATP binding	IEA
ATP hydrolysis activity	IEA