GlyCosmos Portal

Annotation

Keyword

3D-structure
Brugada syndrome
Cytoplasm
Disease variant
NAD
Oxidoreductase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N335

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
regulation of heart rate	IMP	17967977 19666841
carbohydrate metabolic process	IEA
NADH oxidation	IBA
NADH metabolic process
positive regulation of sodium ion transport	IMP	17967977 19666841 19745168

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

catabolic process [inference]

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

glycerol-3-phosphate catabolic process

carbohydrate derivative catabolic process [inference]

glycerol-3-phosphate catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

organophosphate catabolic process [inference]

glycerol-3-phosphate catabolic process

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

primary metabolic process [inference]

carbohydrate metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

organic substance metabolic process [inference]

carbohydrate metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

organophosphate catabolic process [inference]

glycerol-3-phosphate catabolic process

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate catabolic process

carbohydrate derivative metabolic process [inference]

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate catabolic process

carbohydrate derivative catabolic process [inference]

glycerol-3-phosphate catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

glycerol-3-phosphate catabolic process

carbohydrate derivative catabolic process [inference]

glycerol-3-phosphate catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

organophosphate catabolic process [inference]

glycerol-3-phosphate catabolic process

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process [inference]

glycerol-3-phosphate catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

NADH metabolic process

NADH oxidation

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport [inference]

positive regulation of sodium ion transport

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

positive regulation of protein localization to cell surface

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell surface

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

regulation of cellular process [inference]

regulation of membrane depolarization [inference]

regulation of ventricular cardiac muscle cell membrane depolarization

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell surface

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

positive regulation of protein localization to cell surface

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate

regulation of biological quality [inference]

regulation of heart rate

regulation of membrane potential [inference]

action potential [inference]

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction [inference]

ventricular cardiac muscle cell action potential

regulation of membrane depolarization [inference]

regulation of ventricular cardiac muscle cell membrane depolarization

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol	TAS
cytosol	IBA
plasma membrane	IDA	17967977
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	33961781
sodium channel regulator activity	IMP	17967977 19666841
protein homodimerization activity	IEA
transmembrane transporter binding	IPI	19666841
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

glycerol-3-phosphate dehydrogenase [NAD(P)+] activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

transmembrane transporter binding

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

sodium channel regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GLYCEROL-3-PHOSPHATE DEHYDROGENASE

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
H: Coenzyme transport and metabolism
I: Lipid transport and metabolism

Displaying **all 6** entries
Gene Ontology
NADH oxidation
glycerol-3-phosphate catabolic process
glycerol-3-phosphate metabolic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity
protein homodimerization activity

Displaying **all 6** entries
InterPro
6-phosphogluconate dehydrogenase, domain 2
6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
Glycerol-3-phosphate dehydrogenase, NAD-dependent
NAD(P)-binding domain superfamily

KEGG BRITE Database

Orthology

K00006

Name

glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]

References

8196651

Rhea

RHEA:11092

NAD⁺ + sn-glycerol 3-phosphate

H⁺ + dihydroxyacetone phosphate + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110219	Brugada syndrome 2	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 15 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0001279	Syncope
HP:0001645	Sudden cardiac death
HP:0001649	Tachycardia
HP:0001663	Ventricular fibrillation
HP:0001695	Cardiac arrest
HP:0004308	Ventricular arrhythmia
HP:0004751	Paroxysmal ventricular tachycardia
HP:0004755	Supraventricular tachycardia
HP:0011704	Sick sinus syndrome

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:130	Brugada syndrome
OMIM:611777	Brugada syndrome 2

PubChem Disease

MedGen Diseases

Brugada syndrome 2

OMIM Phenotypes

BRUGADA SYNDROME 2; BRGDA2

KEGG Diseases

Brugada syndrome

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012353
Gene Name: glycerol-3-phosphate dehydrogenase 1-like

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	2819	SGD:S000005420
Saccharomyces cerevisiae S288C	14555	SGD:S000005420
Xenopus tropicalis	23171	Xenbase:XB-GENE-969902
Xenopus tropicalis	33824	Xenbase:XB-GENE-969902
Saccharomyces cerevisiae S288C	60666	SGD:S000005420
Xenopus tropicalis	176399	Xenbase:XB-GENE-969902
Mus musculus	333433	Xenbase:XB-GENE-969902	MOUSE63829
Rattus norvegicus	363159		RATNO42016
Xenopus tropicalis	379962	Xenbase:XB-GENE-969902
Xenopus tropicalis	394623	Xenbase:XB-GENE-969902

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements