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filamin B

Summary

Gene Symbol

FLNB

Organism

Homo sapiens (human)

External Links

NCBI Gene

2317

PubChem

2317

Alliance of Genome Resources

HGNC:3755

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Cytoskeleton
Developmental protein
Differentiation
Disease variant
Dwarfism
Isopeptide bond
Myogenesis
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O75369	ABP-278 ABP-280 homolog Actin-binding-like protein Beta-filamin Filamin homolog 1 Filamin-3 Thyroid autoantigen Truncated actin-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
actin cytoskeleton organization	IEA
keratinocyte development	IEA
skeletal muscle tissue development	IEA
cellular response to type II interferon	IEA
epithelial cell morphogenesis	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

actin filament-based process [inference]

actin cytoskeleton organization

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

keratinocyte development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

epithelial cell morphogenesis

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

skeletal muscle tissue development

cell development [inference]

epithelial cell development [inference]

keratinocyte development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

keratinocyte development

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

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GO Term	Evidence Code	PMID
stress fiber	IEA
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell cortex

cytosol

membrane

plasma membrane

Z disc

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cluster of actin-based cell projections [inference]

brush border

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GO Term	Evidence Code	PMID
protein binding	IPI	10644691 10676904 12393796 12577067 16076904 17474147 19270716
actin binding	NAS	8327473
actin filament binding	IEA
identical protein binding	IPI	12393796
RNA binding	HDA	22681889

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

identical protein binding

cell adhesion molecule binding [inference]

cadherin binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

filamin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
actin cytoskeleton organization
actin filament binding

Displaying **all 5** entries
InterPro
Filamin family
Filamin/ABP280 repeat-like
Filamin/ABP280 repeat
Immunoglobulin E-set
Immunoglobulin-like fold

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:423	myopathy	Alliance of Genome Resources
DOID:674	cleft palate	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Orthologous MAtrix
Macaca nemestrina	105482823	MACNE24741
Mandrillus leucophaeus	105552667	MANLE03458
Cercocebus atys	105585619	CERAT02117
Aotus nancymaae	105724308	AOTNA26559
Propithecus coquereli	105827321	PROCO00489
Microcebus murinus	105884913	MICMU11119
Dipodomys ordii	105981360	DIPOR02627
Equus asinus asinus	106848649	EQUAS01002
Sinocyclocheilus grahami	107557390	SINGR71227
Ictalurus punctatus	108254750	ICTPU16586

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements