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proteasome activator subunit 4

Summary

Gene Symbol

PSME4

Organism

Homo sapiens (human)

External Links

NCBI Gene

23198

PubChem

23198

Alliance of Genome Resources

HGNC:20635

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
DNA repair
Developmental protein
Nucleus
Phosphoprotein
Proteasome
Reference proteome
Repeat
Spermatogenesis

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14997	Proteasome activator PA200

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA repair	ISS
cellular response to DNA damage stimulus	ISS
DNA damage response	ISS
proteasomal ubiquitin-independent protein catabolic process	ISS
proteasomal ubiquitin-independent protein catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

sperm DNA condensation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

sperm DNA condensation

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

sperm DNA condensation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	IBA
nucleus	HDA	21630459
nucleoplasm	IDA
cytosol	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

proteasome complex [inference]

spermatoproteasome complex

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex [inference]

spermatoproteasome complex

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	18845680 25416956 35271311
peptidase activator activity	ISS
peptidase activator activity	IBA
lysine-acetylated histone binding	ISS
lysine-acetylated histone binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

histone binding [inference]

lysine-acetylated histone binding

modification-dependent protein binding [inference]

acetylation-dependent protein binding [inference]

lysine-acetylated histone binding

protein-containing complex binding [inference]

proteasome binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity

peptidase regulator activity [inference]

peptidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proteasome activator

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
DNA repair
lysine-acetylated histone binding
peptidase activator activity
proteasomal ubiquitin-independent protein catabolic process
proteasome binding

Displaying **all 4** entries
InterPro
Armadillo-type fold
Proteasome activator Blm10, mid region
Proteasome activator complex subunit 4 C-terminal domain
Proteasome activator complex subunit 4