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proteasome activator subunit 4

Summary

Gene Symbol

PSME4

Organism

Homo sapiens (human)

External Links

NCBI Gene

23198

PubChem

23198

Alliance of Genome Resources

HGNC:20635

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
DNA repair
Developmental protein
Nucleus
Phosphoprotein
Proteasome
Reference proteome
Repeat
Spermatogenesis

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14997	Proteasome activator PA200

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA repair	ISS
DNA damage response	ISS
cellular response to DNA damage stimulus	ISS
proteasomal ubiquitin-independent protein catabolic process	ISS
proteasomal ubiquitin-independent protein catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasomal ubiquitin-independent protein catabolic process

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

sperm DNA condensation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

sperm DNA condensation

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

sperm DNA condensation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	IBA
nucleus	HDA	21630459
nucleoplasm	IDA
cytosol	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

proteasome complex [inference]

spermatoproteasome complex

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex [inference]

spermatoproteasome complex

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	18845680 25416956 35271311
peptidase activator activity	ISS
peptidase activator activity	IBA
lysine-acetylated histone binding	ISS
lysine-acetylated histone binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

histone binding [inference]

lysine-acetylated histone binding

modification-dependent protein binding [inference]

acetylation-dependent protein binding [inference]

lysine-acetylated histone binding

protein-containing complex binding [inference]

proteasome binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity

peptidase regulator activity [inference]

peptidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proteasome activator

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
DNA repair
lysine-acetylated histone binding
peptidase activator activity
proteasomal ubiquitin-independent protein catabolic process
proteasome binding

Displaying **all 4** entries
InterPro
Armadillo-type fold
Proteasome activator Blm10, mid region
Proteasome activator complex subunit 4 C-terminal domain
Proteasome activator complex subunit 4

Ortholog

Displaying entries **1 - 10** of 96 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	23198	Xenbase:XB-GENE-5841406
Mus musculus	103554		MOUSE03716
Pan troglodytes	459229		PANTR27608
Canis lupus familiaris	474594		CANLF01839
Rattus norvegicus	498433		RATNO09104
Bos taurus	528142		BOVIN02382
Danio rerio	553346		DANRE04148
Macaca mulatta	716580		MACMU08211
Monodelphis domestica	100033340		MONDO05371
Equus caballus	100066926		HORSE10452