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spectrin repeat containing nuclear envelope protein 2

Summary

Gene Symbol

SYNE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23224

PubChem

23224

Alliance of Genome Resources

HGNC:17084

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Cell junction
Cell membrane
Coiled coil
Cytoskeleton
Disease variant
Disulfide bond
Emery-Dreifuss muscular dystrophy
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome
Repeat
Sarcoplasmic reticulum
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8WXH0	KASH domain-containing protein 2 Nuclear envelope spectrin repeat protein 2 Nucleus and actin connecting element protein Synaptic nuclear envelope protein 2
Q6MZP0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
nuclear migration along microfilament	ISS

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based process [inference]

actin filament-based movement [inference]

nuclear migration along microfilament

cellular localization [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

microtubule organizing center localization [inference]

centrosome localization

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

microtubule-based transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

establishment of organelle localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

organelle localization [inference]

nucleus localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

establishment of organelle localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

cellular localization [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

microtubule organizing center localization [inference]

centrosome localization

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle assembly [inference]

regulation of cilium assembly

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of cilium assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
sarcoplasmic reticulum membrane	IEA
intermediate filament cytoskeleton	IDA
nuclear membrane	IDA
focal adhesion	IDA	15671068
filopodium membrane	IDA	15671068

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

nuclear membrane protein complex [inference]

nuclear membrane microtubule tethering complex [inference]

meiotic nuclear membrane microtubule tethering complex

nuclear protein-containing complex [inference]

nuclear membrane protein complex [inference]

nuclear membrane microtubule tethering complex [inference]

meiotic nuclear membrane microtubule tethering complex

cellular anatomical entity [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

sarcoplasmic reticulum membrane

nuclear membrane

nuclear outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

sarcoplasmic reticulum membrane

plasma membrane region [inference]

cell projection membrane [inference]

Z disc

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

lamellipodium membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

nuclear lumen

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15671068 17462627 18396275 19933576 22555292 22632968 23414517 23977161 24880667 26506308 28716842 30833792 32296183 33058875 34818527
actin binding	ISS
cytoskeleton-nuclear membrane anchor activity	IDA	18396275

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-membrane adaptor activity [inference]

cytoskeleton-nuclear membrane anchor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-actinin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
CH domain superfamily
Calponin homology domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0070250	autosomal dominant Emery-Dreifuss muscular dystrophy 5	Alliance of Genome Resources
DOID:11383	cryptorchidism	Alliance of Genome Resources
DOID:11726	Emery-Dreifuss muscular dystrophy	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 45 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Ornithorhynchus anatinus	100081014		ORNAN05762
Taeniopygia guttata	100227700		TAEGU25626
Callithrix jacchus	100391491		CALJA00464
Pongo abelii	100459950	9601_0:0037de	PONAB08012
Ailuropoda melanoleuca	100471746		AILME17922
Sus scrofa	100524661		PIGXX15305
Meleagris gallopavo	100543155		MELGA11171
Nomascus leucogenys	100596530		NOMLE17416
Cavia porcellus	100716463		CAVPO10527
Cricetulus griseus	100767452		CRIGR05924