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spectrin repeat containing nuclear envelope protein 2

Summary

Gene Symbol

SYNE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23224

PubChem

23224

Alliance of Genome Resources

HGNC:17084

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Cell junction
Cell membrane
Coiled coil
Cytoskeleton
Disease variant
Disulfide bond
Emery-Dreifuss muscular dystrophy
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome
Repeat
Sarcoplasmic reticulum
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8WXH0	KASH domain-containing protein 2 Nuclear envelope spectrin repeat protein 2 Nucleus and actin connecting element protein Synaptic nuclear envelope protein 2
Q6MZP0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nuclear migration	IMP	20724637
centrosome localization	IMP	20724637
positive regulation of cell migration	ISS
regulation of cilium assembly	IEA
nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based process [inference]

actin filament-based movement [inference]

nuclear migration along microfilament

cellular localization [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

microtubule organizing center localization [inference]

centrosome localization

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

microtubule-based transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

establishment of organelle localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

organelle localization [inference]

nucleus localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

establishment of organelle localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

cellular localization [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

microtubule organizing center localization [inference]

centrosome localization

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle assembly [inference]

regulation of cilium assembly

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of cilium assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
sarcoplasmic reticulum membrane	IEA
intermediate filament cytoskeleton	IDA
nuclear membrane	IDA
focal adhesion	IDA	15671068
filopodium membrane	IDA	15671068

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

nuclear membrane protein complex [inference]

nuclear membrane microtubule tethering complex [inference]

meiotic nuclear membrane microtubule tethering complex

nuclear protein-containing complex [inference]

nuclear membrane protein complex [inference]

nuclear membrane microtubule tethering complex [inference]

meiotic nuclear membrane microtubule tethering complex

cellular anatomical entity [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

sarcoplasmic reticulum membrane

nuclear membrane

nuclear outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

sarcoplasmic reticulum membrane

plasma membrane region [inference]

cell projection membrane [inference]

Z disc

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

lamellipodium membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

nuclear lumen

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15671068 17462627 18396275 19933576 22555292 22632968 23414517 23977161 24880667 26506308 28716842 30833792 32296183 33058875 34818527
actin binding	ISS
cytoskeleton-nuclear membrane anchor activity	IDA	18396275

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-membrane adaptor activity [inference]

cytoskeleton-nuclear membrane anchor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-actinin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
CH domain superfamily
Calponin homology domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0070250	autosomal dominant Emery-Dreifuss muscular dystrophy 5	Alliance of Genome Resources
DOID:11383	cryptorchidism	Alliance of Genome Resources
DOID:11726	Emery-Dreifuss muscular dystrophy	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 45 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Sarcophilus harrisii	100917208		SARHA02665
Pan paniscus	100987774	9597_0:0039ea
Papio anubis	101010608		PAPAN36654
Saimiri boliviensis boliviensis	101046076		SAIBB07594
Gorilla gorilla gorilla	101142098	9595_0:003e85	GORGO09085
Tursiops truncatus	101321981		TURTR14374
Mustela putorius furo	101673979		MUSPF19191
Equus caballus	102148544		HORSE22494
Capra hircus	102184156		CAPHI00302
Myotis lucifugus	102430468		MYOLU14332