GlyCosmos Portal

Submissions

fms related receptor tyrosine kinase 3 ligand

Summary

Gene Symbol

FLT3LG

Organism

Homo sapiens (human)

External Links

NCBI Gene

2323

PubChem

2323

Alliance of Genome Resources

HGNC:3766

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytokine
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P49771	SL cytokine
B7ZLY4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
signal transduction	TAS	8180375
positive regulation of cell population proliferation	IDA	8180375
positive regulation of cell population proliferation	IBA
B cell differentiation	IMP	38701783
embryonic hemopoiesis	IDA	21149635

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

signal transduction

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

dendritic cell differentiation

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

animal organ development [inference]

embryonic organ development [inference]

embryonic hemopoiesis

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

dendritic cell differentiation

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IBA
cytosol	TAS
plasma membrane	IEA
cell surface	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
signaling receptor binding	TAS	8180375
cytokine activity	IEA
protein binding	IPI	32296183 32814053
receptor tyrosine kinase binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

receptor tyrosine kinase binding

receptor ligand activity [inference]

cytokine activity

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fms-related tyrosine kinase 3 ligand

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cytokine activity
kinase activity
phosphorylation
positive regulation of cell population proliferation
receptor tyrosine kinase binding

Displaying **all 2** entries
InterPro
Flt3 ligand
Four-helical cytokine-like, core

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1520	colon carcinoma	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 28 in total

1

2

3

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	2323	Xenbase:XB-GENE-22201454
Mus musculus	14256	RGD:2322792	MOUSE53972
Bos taurus	282233		BOVIN11521
Rattus norvegicus	317646		RATNO18426
Felis catus	493796		FELCA34745
Pongo abelii	100439816		PONAB14348
Pan troglodytes	100610021		PANTR18924
Cavia porcellus	100723994		CAVPO19359
Cricetulus griseus	100773162		CRIGR18304
Papio anubis	101007432		PAPAN22342

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements