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protein O-fucosyltransferase 2

Summary

Gene Symbol

POFUT2

Aliases

FUT13
GDP-fucose protein O-fucosyltransferase 2
KIAA0958
peptide-O-fucosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

23275

GGDB ID

gg013

HGNC

14683

mRNA

NM_133635

map

21q22.3

Protein

NP_598368

OMIM

610249

KEGG Gene ID

hsa:23275

PubChem

23275

Alliance of Genome Resources

HGNC:14683

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Endoplasmic reticulum
Fucose metabolism
Glycoprotein
Glycosyltransferase
Golgi apparatus
Proteomics identification
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
S6FW71	Peptide-O-fucosyltransferase 2
Q9Y2G5	Peptide-O-fucosyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mesoderm formation	IEA
regulation of gene expression	IEA
positive regulation of protein folding	IMP	25544610
regulation of secretion	IDA	17395589
fucose metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

glycosylation [inference]

fucosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein folding

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of protein folding

regulation of protein folding [inference]

positive regulation of protein folding

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
Golgi apparatus	IDA	15233996

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying 1 entry
GO Term	Evidence Code	PMID
peptide-O-fucosyltransferase activity	IBA IDA TAS	22588082

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity [inference]

peptide-O-fucosyltransferase activity

catalytic activity, acting on a protein [inference]

peptide-O-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg013

Gene Symbol

POFUT2

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Rattus norvegicus	XP_228073	XM_228073
Drosophila melanogaster	NP_569916	NM_130560
Caenorhabditis elegans	NP_741272	NM_171228
Mus musculus	NP_084538	NM_030262

KEGG BRITE Database

Orthology

K03691

Name

peptide-O-fucosyltransferase [EC:2.4.1.221]

References

11524432

Rhea

RHEA:63644

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

RHEA:70539

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

RHEA:70491

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

RHEA:70535

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0060055	popliteal pterygium syndrome	DisGeNET
DOID:0080201	Peters plus syndrome	DisGeNET
DOID:12365	malaria	DisGeNET
DOID:14250	Down syndrome	Alliance of Genome Resources
DOID:5212	congenital disorder of glycosylation	DisGeNET
DOID:5419	schizophrenia	DisGeNET

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	259529	WB:WBGene00010757
Drosophila melanogaster	31098	FB:FBgn0027791
Ciona intestinalis	445727		CIOIN00351
Callorhinchus milii	103176848		CALMI11534
Latimeria chalumnae	102348539		LATCH04826
Danio rerio	777668	ZFIN:ZDB-GENE-030131-3595	DANRE45274
Astyanax mexicanus	103028255		ASTMX07877
Electrophorus electricus	113581337		ELEEL18677
Salmo salar	106582296		SALSA100980
Salmo salar	106586440		SALSA111708

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements