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ATPase, Na+/K+ transporting, alpha 3 polypeptide

Summary

Gene Symbol

Atp1a3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

232975

PubChem

232975

Alliance of Genome Resources

MGI:88107

Annotation

Keyword

ATP-binding
Cell membrane
Direct protein sequencing
Magnesium
Metal-binding
Phosphoprotein
Potassium transport
Proteomics identification
Reference proteome
Sodium/potassium transport
Translocase
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8VCE0
Q8R0E8
Q6PIC6	Na(+)/K(+) ATPase alpha(III) subunit Sodium pump subunit alpha-3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **46 - 50** of 63 in total

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GO Term	Evidence Code	PMID
sodium ion transport	ISO
thalamus development	IMP	23527305
response to methamphetamine hydrochloride	IMP	20850480
calcium-mediated signaling	IMP	22025725
response to acid chemical	IMP	22025725

GO Hierarchy

biological process

metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

L-ascorbic acid metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

organic cyclic compound metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

brain-derived neurotrophic factor receptor signaling pathway

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

second-messenger-mediated signaling [inference]

calcium-mediated signaling

phosphatidylinositol 3-kinase/protein kinase B signal transduction

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

pore complex assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection organization [inference]

neuron projection maintenance

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

pore complex assembly

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

circulatory system process [inference]

blood circulation

nervous system process [inference]

transmission of nerve impulse

cognition

learning or memory [inference]

learning

associative learning [inference]

visual learning

nonassociative learning [inference]

habituation

memory

neuromuscular process

neuromuscular process controlling balance

behavior

learning or memory [inference]

learning

associative learning [inference]

visual learning

nonassociative learning [inference]

habituation

memory

locomotory behavior

visual behavior [inference]

visual learning

adult behavior [inference]

adult locomotory behavior

multicellular organismal response to stress [inference]

fear response

multicellular organism growth

developmental process [inference]

anatomical structure development [inference]

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

growth [inference]

developmental growth [inference]

multicellular organism growth

locomotion

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to stress

multicellular organismal response to stress [inference]

fear response

response to immobilization stress

response to external stimulus [inference]

response to environmental enrichment

response to abiotic stimulus [inference]

response to temperature stimulus

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to electrical stimulus

response to endogenous stimulus [inference]

response to hormone

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to activity

response to chemical

response to organic substance [inference]

response to hormone

response to organonitrogen compound [inference]

response to amine [inference]

response to methamphetamine hydrochloride

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to monoamine

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to inorganic substance [inference]

response to metal ion [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to methamphetamine hydrochloride

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to monoamine

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to oxygen-containing compound [inference]

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to salt [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

sodium ion transport

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport

organic acid transport [inference]

carboxylic acid transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

brain-derived neurotrophic factor receptor signaling pathway

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

second-messenger-mediated signaling [inference]

calcium-mediated signaling

phosphatidylinositol 3-kinase/protein kinase B signal transduction

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

Displaying entries **16 - 20** of 22 in total

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GO Term	Evidence Code	PMID
sodium:potassium-exchanging ATPase complex	IDA ISO	19376779
Golgi apparatus	ISO
protein-containing complex	IDA	17804407
presynaptic membrane	ISO
organelle membrane	ISO

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

sodium:potassium-exchanging ATPase complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

sodium:potassium-exchanging ATPase complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

sodium:potassium-exchanging ATPase complex

cellular anatomical entity [inference]

membrane

plasma membrane

sarcolemma

organelle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse

neuron to neuron synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus [inference]

calyx of Held

presynapse [inference]

axon terminus [inference]

calyx of Held

postsynapse

Displaying entries **11 - 12** of 12 in total

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GO Term	Evidence Code	PMID
P-type potassium transmembrane transporter activity	IEA
nucleotide binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

sodium ion transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

sodium ion transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

sodium ion transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

dopamine receptor binding [inference]

D1 dopamine receptor binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

protein-folding chaperone binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

heparan sulfate proteoglycan binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050635	alternating hemiplegia of childhood	Alliance of Genome Resources
DOID:0060178	familial hemiplegic migraine	Alliance of Genome Resources
DOID:0070385	developmental and epileptic encephalopathy 99	Alliance of Genome Resources
DOID:0090056	dystonia 12	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:3312	bipolar disorder	Alliance of Genome Resources
DOID:863	nervous system disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179796	WB:WBGene00001137
Drosophila melanogaster	48971	FB:FBgn0002921
Danio rerio	64610	ZFIN:ZDB-GENE-001212-7	DANRE14896
Danio rerio	64611	ZFIN:ZDB-GENE-001212-8	DANRE11218
Astyanax mexicanus	103030580		ASTMX08739
Astyanax mexicanus	103034051		ASTMX06759
Ictalurus punctatus	108266346		ICTPU13681
Ictalurus punctatus	108272709		ICTPU03673
Electrophorus electricus	113581248		ELEEL27070
Salmo salar	106583316		SALSA104532

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Acknowledgements