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ATPase, Na+/K+ transporting, alpha 3 polypeptide

Summary

Gene Symbol

Atp1a3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

232975

PubChem

232975

Alliance of Genome Resources

MGI:88107

Annotation

Keyword

ATP-binding
Cell membrane
Direct protein sequencing
Magnesium
Metal-binding
Phosphoprotein
Potassium transport
Proteomics identification
Reference proteome
Sodium/potassium transport
Translocase
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8VCE0
Q8R0E8
Q6PIC6	Na(+)/K(+) ATPase alpha(III) subunit Sodium pump subunit alpha-3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 63 in total

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GO Term	Evidence Code	PMID
response to lithium ion	IMP	22025725
response to environmental enrichment	IMP	26501181
ion transport	IEA
habituation	IMP	26501181
response to temperature stimulus	IMP	20850480

GO Hierarchy

biological process

metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

L-ascorbic acid metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

organic cyclic compound metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

brain-derived neurotrophic factor receptor signaling pathway

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

second-messenger-mediated signaling [inference]

calcium-mediated signaling

phosphatidylinositol 3-kinase/protein kinase B signal transduction

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

pore complex assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection organization [inference]

neuron projection maintenance

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

pore complex assembly

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

circulatory system process [inference]

blood circulation

nervous system process [inference]

transmission of nerve impulse

cognition

learning or memory [inference]

learning

associative learning [inference]

visual learning

nonassociative learning [inference]

habituation

memory

neuromuscular process

neuromuscular process controlling balance

behavior

learning or memory [inference]

learning

associative learning [inference]

visual learning

nonassociative learning [inference]

habituation

memory

locomotory behavior

visual behavior [inference]

visual learning

adult behavior [inference]

adult locomotory behavior

multicellular organismal response to stress [inference]

fear response

multicellular organism growth

developmental process [inference]

anatomical structure development [inference]

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

growth [inference]

developmental growth [inference]

multicellular organism growth

locomotion

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to stress

multicellular organismal response to stress [inference]

fear response

response to immobilization stress

response to external stimulus [inference]

response to environmental enrichment

response to abiotic stimulus [inference]

response to temperature stimulus

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to electrical stimulus

response to endogenous stimulus [inference]

response to hormone

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to activity

response to chemical

response to organic substance [inference]

response to hormone

response to organonitrogen compound [inference]

response to amine [inference]

response to methamphetamine hydrochloride

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to monoamine

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to inorganic substance [inference]

response to metal ion [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to methamphetamine hydrochloride

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to monoamine

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to oxygen-containing compound [inference]

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to salt [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

sodium ion transport

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport

organic acid transport [inference]

carboxylic acid transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

brain-derived neurotrophic factor receptor signaling pathway

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

second-messenger-mediated signaling [inference]

calcium-mediated signaling

phosphatidylinositol 3-kinase/protein kinase B signal transduction

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

Displaying entries **6 - 10** of 22 in total

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GO Term	Evidence Code	PMID
axon	ISO
postsynapse	ISO
neuronal cell body	ISO
synapse	ISO
cell surface	IDA	17804407

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

sodium:potassium-exchanging ATPase complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

sodium:potassium-exchanging ATPase complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

sodium:potassium-exchanging ATPase complex

cellular anatomical entity [inference]

membrane

plasma membrane

sarcolemma

organelle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse

neuron to neuron synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus [inference]

calyx of Held

presynapse [inference]

axon terminus [inference]

calyx of Held

postsynapse

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
P-type sodium:potassium-exchanging transporter activity	IBA IDA ISO	19666602 21418141
transporter activity	IEA
amyloid-beta binding	ISO
P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential	IGI	19376779
protein-folding chaperone binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

sodium ion transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

sodium ion transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

sodium ion transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

dopamine receptor binding [inference]

D1 dopamine receptor binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

protein-folding chaperone binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

heparan sulfate proteoglycan binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

P-type potassium transmembrane transporter activity

P-type sodium:potassium-exchanging transporter activity

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050635	alternating hemiplegia of childhood	Alliance of Genome Resources
DOID:0060178	familial hemiplegic migraine	Alliance of Genome Resources
DOID:0070385	developmental and epileptic encephalopathy 99	Alliance of Genome Resources
DOID:0090056	dystonia 12	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:3312	bipolar disorder	Alliance of Genome Resources
DOID:863	nervous system disease	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 70 in total

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Species	Gene ID	Orthologous MAtrix
Ornithorhynchus anatinus	100088125	ORNAN22673
Callithrix jacchus	100410682	CALJA22705
Cercocebus atys	105598041	CERAT40239
Macaca mulatta	706513	MACMU19498
Macaca nemestrina	105495619	MACNE25897
Papio anubis	101015462	PAPAN23436
Mandrillus leucophaeus	105542535	MANLE18868
Gorilla gorilla gorilla	101136136	GORGO16099
Pan troglodytes	456068	PANTR18414
Pongo abelii	100440055	PONAB14404

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GlyComb

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UniCarb-DR

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Acknowledgements