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VPS39 subunit of HOPS complex

Summary

Gene Symbol

VPS39

Organism

Homo sapiens (human)

External Links

NCBI Gene

23339

PubChem

23339

Alliance of Genome Resources

HGNC:20593

Annotation

Keyword

3D-structure
Alternative splicing
Autophagy
Cytoplasm
Endosome
Host-virus interaction
Lysosome
Membrane
Protein transport
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96JC1	TRAP1-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
autophagy	IBA IMP	24554770
endocytic recycling	IMP	25266290
late endosome to lysosome transport	IDA	23167963
endosome to lysosome transport	IMP	25266290 25783203
autophagosome-lysosome fusion	IDA	33422265

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular process [inference]

vesicle-mediated transport [inference]

endosome to lysosome transport

endosomal transport [inference]

endocytic recycling

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosomal transport [inference]

endocytic recycling

localization within membrane [inference]

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle fusion [inference]

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosome to lysosome transport

endosomal transport [inference]

endocytic recycling

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosomal transport [inference]

endocytic recycling

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosomal transport [inference]

endocytic recycling

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosomal transport [inference]

endocytic recycling

localization within membrane [inference]

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of SNARE complex assembly

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of SNARE complex assembly

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
membrane	IBA
late endosome	IDA	33422265
HOPS complex	IDA NAS	19109425 23901104 24554770
late endosome membrane	IDA	23167963
AP-3 adaptor complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

AP-type membrane coat adaptor complex [inference]

AP-3 adaptor complex

HOPS complex

vacuolar HOPS complex [inference]

lysosomal HOPS complex

vesicle tethering complex [inference]

HOPS complex

vacuolar HOPS complex [inference]

lysosomal HOPS complex

cellular anatomical entity [inference]

cytoplasm

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

late endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	23901104 24554770 28325809 28514442 31806350 32296183 32353859 32838362 33060197 33422265 33452816 33845483 33947832 33961781 34232536 34706264 35271311 36217030

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Vacuolar protein

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
endosomal vesicle fusion

Displaying **all 4** entries
InterPro
Citron homology (CNH) domain
Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1
Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2
Vam6/VPS39/TRAP1 family

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	42192		FB:FBgn0038593
Caenorhabditis elegans	179902		WB:WBGene00011625
Mus musculus	269338		MGI:2443189	MOUSE31862
Rattus norvegicus	362199		RGD:1304858	RATNO26740
Pan troglodytes	453358	9598_0:003f17		PANTR10072
Canis lupus familiaris	487516			CANLF12430
Bos taurus	520990			BOVIN01084
Danio rerio	567078		ZFIN:ZDB-GENE-080530-2	DANRE11997
Macaca mulatta	707791			MACMU41352
Saccharomyces cerevisiae S288C	851482		SGD:S000002235