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tensin 2

Summary

Gene Symbol

TNS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23371

PubChem

23371

Alliance of Genome Resources

HGNC:19737

Annotation

Keyword

3D-structure
Alternative splicing
Cell junction
Cell membrane
Cytoplasm
Lipid-binding
Methylation
Phosphoprotein
Protein phosphatase
Reference proteome
SH2 domain
Ubl conjugation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q63HR2	C1 domain-containing phosphatase and tensin homolog Tensin-like C1 domain-containing phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cellular homeostasis	IEA
collagen metabolic process	IEA
multicellular organism growth	IEA
negative regulation of insulin receptor signaling pathway	IBA IDA	23401856
peptidyl-tyrosine dephosphorylation	IDA	23401856

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

collagen metabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation

multicellular organismal process [inference]

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

response to stimulus [inference]

response to activity [inference]

response to muscle activity

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
focal adhesion	HDA IBA IDA	16951145 21423176 22019427
plasma membrane	IEA
cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
kinase binding	IPI	22019427
protein binding	IPI	16273093 16951145 17190795 24728074 25416956 25814554 26871637 27107012 32296183
protein tyrosine phosphatase activity	IBA IDA	23401856
metal ion binding	IEA
identical protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding

identical protein binding

lipid binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tensin

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
PH-like domain superfamily
SH2 domain superfamily
SH2 domain
Tensin/EPS8 phosphotyrosine-binding domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060852	Pierson syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	41144		FB:FBgn0000244
Caenorhabditis elegans	172215		WB:WBGene00006508
Mus musculus	209039		MGI:2387586	MOUSE16794
Rattus norvegicus	315326		RGD:1310917	RATNO38386
Pan troglodytes	451927	9598_0:0035c3		PANTR05777
Canis lupus familiaris	477599			CANLF10748
Danio rerio	565809		ZFIN:ZDB-GENE-101001-5
Macaca mulatta	700813			MACMU05182
Danio rerio	799109		ZFIN:ZDB-GENE-090312-163	DANRE25105
Equus caballus	100146672			HORSE37195