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SET domain containing 1A

Summary

Gene Symbol

Setd1a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

233904

PubChem

233904

Alliance of Genome Resources

MGI:2446244

Annotation

Keyword

Activator
Chromatin regulator
Chromosome
Cytoplasm
DNA damage
Methyltransferase
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
S-adenosyl-L-methionine
Transcription regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
E9PYH6	SET domain-containing protein 1A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
positive regulation of neural precursor cell proliferation	IMP	24550110
regulation of chromatin organization	IDA ISO	27141965
brain development	IMP ISO	31197650
stem cell population maintenance	IMP	24550110
positive regulation of stem cell proliferation	IMP	24550110

GO Hierarchy

biological process

metabolic process [inference]

methylation

cellular process [inference]

cell population proliferation [inference]

stem cell proliferation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

transcription initiation-coupled chromatin remodeling

multicellular organismal process [inference]

stem cell population maintenance

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

maintenance of cell number [inference]

stem cell population maintenance

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

regulation of stem cell proliferation [inference]

positive regulation of stem cell proliferation

regulation of neural precursor cell proliferation [inference]

positive regulation of neural precursor cell proliferation

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular component organization [inference]

regulation of chromatin organization

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of erythrocyte differentiation

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nuclear speck	ISO ISS
euchromatin	IDA	22723415
Set1C/COMPASS complex	IBA ISO TAS	27141965
chromatin	ISO
histone methyltransferase complex	ISO TAS	17500065 22723415

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

euchromatin

nuclear protein-containing complex [inference]

histone methyltransferase complex

Set1C/COMPASS complex

catalytic complex [inference]

transferase complex [inference]

methyltransferase complex [inference]

histone methyltransferase complex

Set1C/COMPASS complex

cellular anatomical entity [inference]

cytoplasm

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
histone H3K4 trimethyltransferase activity	IEA
protein binding	IPI	29490266
RNA polymerase II-specific DNA-binding transcription factor binding	ISO
histone H3K4 monomethyltransferase activity	IEA
histone H3K4 methyltransferase activity	IBA IMP ISO NAS TAS	22723415 24550110 27141965 29490266

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

N-methyltransferase activity [inference]

lysine N-methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K4 methyltransferase activity

protein methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone methyltransferase activity [inference]

histone H3 methyltransferase activity [inference]

histone H3K4 methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

lysine N-methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K4 methyltransferase activity

catalytic activity, acting on a protein [inference]

protein methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone methyltransferase activity [inference]

histone H3 methyltransferase activity [inference]

histone H3K4 methyltransferase activity

histone modifying activity [inference]

histone methyltransferase activity [inference]

histone H3 methyltransferase activity [inference]

histone H3K4 methyltransferase activity

binding [inference]

protein binding

beta-catenin binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

histone-lysine N-methyltransferase SETD1A

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
histone H3K4 methyltransferase activity
methylation
transferase activity

Displaying **all 10** entries
InterPro
COMPASS complex Set1 subunit, N-SET domain
Histone-lysine N-methyltransferase SETD1A/B-like, SET domain
Histone-lysine N-methyltransferase Set1-like
Nucleotide-binding alpha-beta plait domain superfamily
Post-SET domain
RNA recognition motif domain
RNA-binding domain superfamily
SET domain superfamily
SET domain
Set1A, RNA recognition motif

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0070417	neurodevelopmental disorder with speech impairment and dysmorphic facies	Alliance of Genome Resources
DOID:0070471	early-onset epilepsy 2	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9739		HGNC:29010	HUMAN27930
Caenorhabditis elegans	175662		WB:WBGene00004782
Rattus norvegicus	309001	10116_1:00006d	RGD:1311624	RATNO17918
Pan troglodytes	468101			PANTR12196
Canis lupus familiaris	489916			CANLF16375
Danio rerio	556535		ZFIN:ZDB-GENE-080521-4	DANRE31504
Macaca mulatta	712416			MACMU27007
Bos taurus	782887			BOVIN20633
Saccharomyces cerevisiae S288C	856519		SGD:S000001161
Drosophila melanogaster	3354971		FB:FBgn0040022

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements