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sirtuin 5

Summary

Gene Symbol

SIRT5

Organism

Homo sapiens (human)

External Links

NCBI Gene

23408

PubChem

23408

Alliance of Genome Resources

HGNC:14933

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Metal-binding
Mitochondrion
NAD
Nucleus
Reference proteome
Transferase
Transit peptide
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NXA8	Regulatory protein SIR2 homolog 5 SIR2-like protein 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein deacetylation	IDA	18680753 22076378
mitochondrion organization	TAS
regulation of ketone biosynthetic process	ISS
negative regulation of cardiac muscle cell apoptotic process	IEA
response to nutrient levels	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein deacylation [inference]

protein deacetylation

protein demalonylation

peptidyl-lysine demalonylation

protein desuccinylation

peptidyl-lysine desuccinylation

protein deglutarylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein deacylation [inference]

protein deacetylation

protein demalonylation

peptidyl-lysine demalonylation

protein desuccinylation

peptidyl-lysine desuccinylation

protein deglutarylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein deacylation [inference]

protein deacetylation

protein demalonylation

peptidyl-lysine demalonylation

protein desuccinylation

peptidyl-lysine desuccinylation

protein deglutarylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein deacylation [inference]

protein deacetylation

protein demalonylation

peptidyl-lysine demalonylation

protein desuccinylation

peptidyl-lysine desuccinylation

protein deglutarylation

macromolecule deacylation [inference]

protein deacylation [inference]

protein deacetylation

protein demalonylation

peptidyl-lysine demalonylation

protein desuccinylation

peptidyl-lysine desuccinylation

protein deglutarylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein deacylation [inference]

protein deacetylation

protein demalonylation

peptidyl-lysine demalonylation

protein desuccinylation

peptidyl-lysine desuccinylation

protein deglutarylation

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

epigenetic regulation of gene expression

regulation of ketone biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

epigenetic regulation of gene expression

regulation of ketone biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

epigenetic regulation of gene expression

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

epigenetic regulation of gene expression

regulation of ketone biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleus	TAS	23806337
nucleus	IBA
mitochondrion	IDA	16079181 23806337
mitochondrion	IBA
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
NAD+ ADP-ribosyltransferase activity	TAS	17456799
zinc ion binding	IDA	22076378
transferase activity
NAD-dependent histone deacetylase activity	IBA
NAD-dependent protein deacetylase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

histone deacetylase activity [inference]

NAD-dependent histone deacetylase activity

deacetylase activity [inference]

protein lysine deacetylase activity [inference]

histone deacetylase activity [inference]

NAD-dependent histone deacetylase activity

NAD-dependent protein deacetylase activity

NAD-dependent histone deacetylase activity

catalytic activity, acting on a protein [inference]

protein lysine deacetylase activity [inference]

histone deacetylase activity [inference]

NAD-dependent histone deacetylase activity

NAD-dependent protein deacetylase activity

NAD-dependent histone deacetylase activity

histone modifying activity [inference]

histone deacetylase activity [inference]

NAD-dependent histone deacetylase activity

NAD+-protein ADP-ribosyltransferase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

ion binding [inference]

anion binding [inference]

NAD+ binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sirtuin

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
NAD+ binding
metal ion binding
transferase activity

Displaying **all 4** entries
InterPro
DHS-like NAD/FAD-binding domain superfamily
Sirtuin family, catalytic core domain
Sirtuin family
Sirtuin, catalytic core small domain superfamily

Ortholog

Displaying entries **1 - 10** of **103** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	23408	Xenbase:XB-GENE-5892372
Mus musculus	68346		MOUSE10314
Rattus norvegicus	306840		RATNO13027
Danio rerio	436878		DANRE18812
Canis lupus familiaris	478726		CANLF13736
Bos taurus	507347		BOVIN19195
Macaca mulatta	700855		MACMU35807
Pan troglodytes	747069		PANTR37259
Equus caballus	100051757		HORSE18578
Ornithorhynchus anatinus	100084511		ORNAN29827