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sirtuin 4

Summary

Gene Symbol

SIRT4

Aliases

SIR2L4

Organism

Homo sapiens (human)

External Links

NCBI Gene

23409

HGNC

14932

PubChem

23409

Alliance of Genome Resources

HGNC:14932

Annotation

Keyword

DNA damage
Direct protein sequencing
Glycosyltransferase
Metal-binding
Mitochondrion
NAD
Nucleotidyltransferase
Reference proteome
Transit peptide
Tumor suppressor
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y6E7	NAD-dependent ADP-ribosyltransferase sirtuin-4 NAD-dependent protein biotinylase sirtuin-4 NAD-dependent protein deacetylase sirtuin-4 Regulatory protein SIR2 homolog 4 SIR2-like protein 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
epigenetic regulation of gene expression	IBA
negative regulation of cardiac muscle cell apoptotic process	IEA
negative regulation of insulin secretion	IMP	17715127
glutamine metabolic process	ISS
peptidyl-lysine deacetylation	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine deacetylation

protein deacylation [inference]

protein deacetylation [inference]

peptidyl-lysine deacetylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

tricarboxylic acid metabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine deacetylation

protein deacylation [inference]

protein deacetylation [inference]

peptidyl-lysine deacetylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

tricarboxylic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

tricarboxylic acid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine deacetylation

protein deacylation [inference]

protein deacetylation [inference]

peptidyl-lysine deacetylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine deacetylation

protein deacylation [inference]

protein deacetylation [inference]

peptidyl-lysine deacetylation

macromolecule deacylation [inference]

protein deacylation [inference]

protein deacetylation [inference]

peptidyl-lysine deacetylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine deacetylation

protein deacylation [inference]

protein deacetylation [inference]

peptidyl-lysine deacetylation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

tricarboxylic acid metabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to stress [inference]

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

epigenetic regulation of gene expression

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing involved in protein targeting to mitochondrion [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

regulation of fatty acid oxidation [inference]

negative regulation of fatty acid oxidation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

epigenetic regulation of gene expression

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing involved in protein targeting to mitochondrion [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing involved in protein targeting to mitochondrion [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing involved in protein targeting to mitochondrion [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

epigenetic regulation of gene expression

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing involved in protein targeting to mitochondrion [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing involved in protein targeting to mitochondrion [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing involved in protein targeting to mitochondrion [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

regulation of fatty acid oxidation [inference]

negative regulation of fatty acid oxidation

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

regulation of primary metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

regulation of fatty acid oxidation [inference]

negative regulation of fatty acid oxidation

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing involved in protein targeting to mitochondrion [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing involved in protein targeting to mitochondrion [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of cellular process [inference]

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

regulation of fatty acid oxidation [inference]

negative regulation of fatty acid oxidation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

epigenetic regulation of gene expression

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of protein processing involved in protein targeting to mitochondrion [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of protein processing involved in protein targeting to mitochondrion

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid oxidation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of oxidoreductase activity [inference]

regulation of pyruvate dehydrogenase activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus
mitochondrial inner membrane	IEA
mitochondrial matrix	IBA IDA TAS	16959573 17715127
mitochondrion	IDA	16079181

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

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GO Term	Evidence Code	PMID
NAD+ ADP-ribosyltransferase activity	IDA TAS	16959573 17456799 17715127
zinc ion binding	IEA
NAD-dependent protein deacetylase activity	IDA	17715127
NAD+- protein-cysteine ADP-ribosyltransferase activity	IEA
NAD+-protein ADP-ribosyltransferase activity	TAS	17456799

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+ ADP-ribosyltransferase activity

NAD+-protein ADP-ribosyltransferase activity

NAD+- protein-cysteine ADP-ribosyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

deacetylase activity [inference]

protein lysine deacetylase activity [inference]

catalytic activity, acting on a protein [inference]

protein lysine deacetylase activity [inference]

histone modifying activity [inference]

histone deacetylase activity

NAD+-protein ADP-ribosyltransferase activity

NAD+- protein-cysteine ADP-ribosyltransferase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

ion binding [inference]

anion binding [inference]

NAD+ binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000089163

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:43636

H₂O + NAD⁺

nicotinamide + 2''-O-acetyl-ADP-D-ribose

Enzyme

2.3.1.286

PMID

Disease

Disease Ontology

Displaying entries **21 - 30** of 70 in total

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DO ID	Disease Name	Source
DOID:1612	breast cancer	DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1749	squamous cell carcinoma	DisGeNET
DOID:1781	thyroid cancer	DisGeNET DisGeNET DisGeNET
DOID:1793	pancreatic cancer	DisGeNET DisGeNET
DOID:1837	diabetic ketoacidosis	DisGeNET
DOID:1936	atherosclerosis	DisGeNET DisGeNET
DOID:2018	hyperinsulinism	DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET DisGeNET
DOID:2871	endometrial carcinoma	DisGeNET DisGeNET DisGeNET

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	181455	WB:WBGene00004801
Caenorhabditis elegans	185876	WB:WBGene00004802
Drosophila melanogaster	31480	FB:FBgn0029783
Ciona intestinalis	778889		CIOIN13083
Callorhinchus milii	103188470		CALMI39172
Latimeria chalumnae	102360444		LATCH19601
Danio rerio	791628	ZFIN:ZDB-GENE-041010-65	DANRE38236
Astyanax mexicanus	103041182		ASTMX09455
Ictalurus punctatus	108272083		ICTPU02557
Salmo trutta	115208069		SALTR35816

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

International Collaboration

Acknowledgements