sirtuin 1

Summary
Gene Symbol
  • SIRT1
Organism
Homo sapiens (human)
NCBI Gene
23411
PubChem
23411
Alliance of Genome Resources
JoGo
SIRT1
TogoVar
SIRT1
Annotation
Keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Apoptosis
  • Biological rhythms
  • Cytoplasm
  • Developmental protein
  • Differentiation
  • Host-virus interaction
  • Metal-binding
  • Methylation
  • Mitochondrion
  • Myogenesis
  • NAD
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • S-nitrosylation
  • Transcription regulation
  • Transferase
  • Ubl conjugation
  • Zinc
Proteins
Displaying all 4 entries
UniProt Protein Name
A8K128
E9PC49
B0QZ35
Q96EB6
  • NAD-dependent protein deacylase sirtuin-1
  • Regulatory protein SIR2 homolog 1
  • SIR2-like protein 1
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
OrthoDB (Group)
Group level
Eukaryota
Group Name
deacetylase
Functional Category
  • M: Cell wall/membrane/envelope biogenesis
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Disease
Disease Ontology
Displaying 1 entry
DO ID Disease Name Source
DOID:12858 Huntington's disease

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 6, 2026