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G protein-coupled receptor 161

Summary

Gene Symbol

GPR161

Organism

Homo sapiens (human)

External Links

NCBI Gene

23432

PubChem

23432

Alliance of Genome Resources

HGNC:23694

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cilium
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8N6U8	G-protein coupled receptor RE2
A0A0A0MQW8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	ISS
G protein-coupled receptor signaling pathway	IBA
adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
recycling endosome	IBA ISS
endocytic vesicle membrane	TAS
plasma membrane	IBA
neuron projection	IEA
glial cell projection	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane

bounding membrane of organelle [inference]

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
G protein-coupled receptor activity	IBA ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Uncharacterized protein

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050902	medulloblastoma	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 83 in total

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Species	Gene ID	Orthologous MAtrix
Macaca nemestrina	105492999	MACNE35694
Mandrillus leucophaeus	105539583	MANLE11612
Cercocebus atys	105600188	CERAT38080
Aotus nancymaae	105711621	AOTNA03696
Propithecus coquereli	105821111	PROCO11095
Microcebus murinus	105881902	MICMU14374
Salmo salar	106581955	SALSA79887
Equus asinus asinus	106841558	EQUAS07868
Sinocyclocheilus grahami	107565954	SINGR80516
Sinocyclocheilus grahami	107595811	SINGR33913