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solute carrier family 35 member A3

Summary

Gene Symbol

SLC35A3

Aliases

UDP-N-acetylglucosamine transporter

Organism

Homo sapiens (human)

External Links

NCBI Gene

23443

GGDB ID

gg174

HGNC

11023

mRNA

NM_012243

map

1p21

Protein

NP_036375

OMIM

605632

KEGG Gene ID

hsa:23443

PubChem

23443

Alliance of Genome Resources

HGNC:11023

Annotation

Keyword

Alternative splicing
Antiport
Autism spectrum disorder
Disease variant
Epilepsy
Golgi apparatus
Intellectual disability
Proteomics identification
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q9Y2D2	Golgi UDP-GlcNAc transporter Solute carrier family 35 member A3
A0A1W2PQL8	Golgi UDP-GlcNAc transporter Solute carrier family 35 member A3
A0A1W2PSD1	Golgi UDP-GlcNAc transporter Solute carrier family 35 member A3
A0A1W2PRT7	Golgi UDP-GlcNAc transporter Solute carrier family 35 member A3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
UDP-N-acetylglucosamine transmembrane transport	IMP	23089177
UDP-N-acetylglucosamine metabolic process		10393322
UDP-galactose transmembrane import into Golgi lumen	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

phosphorus metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

organic substance metabolic process [inference]

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

phosphorus metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

transmembrane transport [inference]

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport [inference]

UDP-galactose transmembrane transport [inference]

UDP-galactose transmembrane import into Golgi lumen

UDP-N-acetylglucosamine transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport [inference]

UDP-galactose transmembrane transport [inference]

UDP-galactose transmembrane import into Golgi lumen

UDP-N-acetylglucosamine transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

UDP-galactose transmembrane transport [inference]

UDP-galactose transmembrane import into Golgi lumen

UDP-N-acetylglucosamine transmembrane transport

nucleobase-containing compound transport [inference]

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport [inference]

UDP-galactose transmembrane transport [inference]

UDP-galactose transmembrane import into Golgi lumen

UDP-N-acetylglucosamine transmembrane transport

carbohydrate derivative transport [inference]

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport [inference]

UDP-galactose transmembrane transport [inference]

UDP-galactose transmembrane import into Golgi lumen

UDP-N-acetylglucosamine transmembrane transport

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport [inference]

UDP-galactose transmembrane transport [inference]

UDP-galactose transmembrane import into Golgi lumen

UDP-N-acetylglucosamine transmembrane transport

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi apparatus		10393322
Golgi membrane	IBA IDA TAS	23766508 28167211

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
antiporter activity	IEA
UDP-N-acetylglucosamine transmembrane transporter activity
UDP-galactose transmembrane transporter activity	IBA
protein binding	IPI	23089177 28167211 34981577

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

UDP-N-acetylglucosamine transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide-sugar transmembrane transporter activity [inference]

pyrimidine nucleotide-sugar transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

nucleotide-sugar transmembrane transporter activity [inference]

pyrimidine nucleotide-sugar transmembrane transporter activity [inference]

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000117620

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg174

Gene Symbol

SLC35A3

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Rattus norvegicus	NP_001012082	NM_001012082
Caenorhabditis elegans	NP_493723	NM_061322
Mus musculus	NP_659151	NM_144902

KEGG BRITE Database

Orthology

K15272

Name

solute carrier family 35 (UDP-sugar transporter), member A1/2/3

References

12759756

Disease

Disease Ontology

Displaying entries **1 - 10** of 21 in total

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DO ID	Disease Name	Source
DOID:0050568	spondylocostal dysostosis	DisGeNET
DOID:0060041	autism spectrum disorder	DisGeNET
DOID:0060249	scoliosis	DisGeNET
DOID:0060823	syndromic X-linked intellectual disability 94	DisGeNET
DOID:1059	intellectual disability	DisGeNET
DOID:10907	microcephaly	DisGeNET
DOID:11832	visual epilepsy	DisGeNET
DOID:12721	multiple epiphyseal dysplasia	DisGeNET
DOID:12804	mucopolysaccharidosis IV	DisGeNET
DOID:12849	autistic disorder	DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 22 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000308	Microretrognathia
HP:0000729	Autistic behavior
HP:0001249	Intellectual disability
HP:0001256	Intellectual disability, mild
HP:0001263	Global developmental delay
HP:0001290	Generalized hypotonia
HP:0001385	Hip dysplasia
HP:0001765	Hammertoe

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:370943	autism spectrum disorder - epilepsy - arthrogryposis syndrome
OMIM:615553	autism spectrum disorder - epilepsy - arthrogryposis syndrome

PubChem Disease

MedGen Diseases

Autism spectrum disorder - epilepsy - arthrogryposis syndrome

OMIM Phenotypes

ARTHROGRYPOSIS, IMPAIRED INTELLECTUAL DEVELOPMENT, AND SEIZURES; AMRS

KEGG Diseases

Arthrogryposis, mental retardation, and seizures

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	173428	WB:WBGene00015404
Callorhinchus milii	103184745		CALMI30574
Latimeria chalumnae	102355386		LATCH10767
Danio rerio	550599	ZFIN:ZDB-GENE-050417-460	DANRE29564
Danio rerio	559707	ZFIN:ZDB-GENE-081105-80
Salmo trutta	115156675		SALTR62325
Salmo trutta	115170043		SALTR41398
Xenopus laevis	379426	Xenbase:XB-GENE-5757952
Xenopus laevis	734793	Xenbase:XB-GENE-1011524
Xenopus laevis	779124	Xenbase:XB-GENE-17345807

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements