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guanylate cyclase 1, soluble, alpha 2

Summary

Gene Symbol

Gucy1a2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

234889

PubChem

234889

Alliance of Genome Resources

MGI:2660877

Annotation

Keyword

Coiled coil
Cytoplasm
GTP-binding
Lyase
Nucleotide-binding
Proteomics identification
Reference proteome
cGMP biosynthesis

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q3TNN8
Q3UH83
F8VQK3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nitric oxide mediated signal transduction	IMP	16614755
positive regulation of nitric oxide mediated signal transduction	IMP	16614755
cGMP-mediated signaling	IBA
response to oxygen levels	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

nitric oxide mediated signal transduction

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling

response to stimulus [inference]

response to abiotic stimulus [inference]

response to oxygen levels

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

nitric oxide mediated signal transduction

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm
guanylate cyclase complex, soluble	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

guanylate cyclase complex, soluble

cellular anatomical entity [inference]

cytoplasm

Displaying **all 5** entries
GO Term	Evidence Code	PMID
guanylate cyclase activity	ISO
guanylate cyclase activity	IBA
GTP binding
heme binding
protein-containing complex binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

cyclase activity [inference]

guanylate cyclase activity

lyase activity [inference]

phosphorus-oxygen lyase activity [inference]

guanylate cyclase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

guanylate cyclase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
GTP binding
cGMP biosynthetic process
cGMP-mediated signaling
cyclic nucleotide biosynthetic process
guanylate cyclase activity
heme binding
lyase activity
phosphorus-oxygen lyase activity
response to oxygen levels

Displaying **all 8** entries
InterPro
Adenylyl cyclase class-3/4/guanylyl cyclase
Adenylyl cyclase class-4/guanylyl cyclase, conserved site
H-NOX domain superfamily
Haem NO binding associated domain superfamily
Haem NO binding associated
Heme NO-binding
NO signalling/Golgi transport ligand-binding domain superfamily
Nucleotide cyclase