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microtubule actin crosslinking factor 1

Summary

Gene Symbol

MACF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

23499

PubChem

23499

Alliance of Genome Resources

HGNC:13664

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Calcium
Cell membrane
Cell projection
Coiled coil
Cytoskeleton
Disease variant
Golgi apparatus
Leucine-rich repeat
Lissencephaly
Metal-binding
Microtubule
Phosphoprotein
Reference proteome
Repeat
SH3 domain
Wnt signaling pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UPN3	620 kDa actin-binding protein Actin cross-linking family protein 7 Macrophin-1 Trabeculin-alpha
Q6ZSD7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
positive regulation of axon extension	IDA	22705394
regulation of neuron projection arborization	ISS
wound healing	IBA ISS
regulation of cell migration	IDA	27693509
Golgi to plasma membrane protein transport	IDA	15265687

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

organic substance transport [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

nitrogen compound transport [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

regulation of epithelial cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of neuron projection arborization

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

regulation of focal adhesion assembly

regulation of microtubule-based process

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of neuron projection arborization

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of cell-substrate junction organization [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cell motility [inference]

regulation of cell migration

regulation of epithelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

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GO Term	Evidence Code	PMID
microtubule	IBA IDA	16076900
membrane	IBA
Golgi apparatus	IDA	15265687 16076900
ruffle membrane	IDA	20937854
plasma membrane	IDA	20937854

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

leading edge membrane [inference]

ruffle membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

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GO Term	Evidence Code	PMID
protein binding	IPI	15265687 17043677 27693509 27802168 31413325
actin binding	IDA	10559237
actin filament binding	IDA NAS	10529403 10559237 27693509
microtubule binding	IEA
RNA binding	HDA	22681889

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

tubulin binding [inference]

microtubule binding

microtubule minus-end binding

cell adhesion molecule binding [inference]

cadherin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

microtubule-actin cross-linking factor 1 isoform X1

Functional Category

C: Energy production and conversion
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 21 in total

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Gene Ontology
Golgi to plasma membrane protein transport
actin binding
actin cytoskeleton organization
actin filament binding
cadherin binding
calcium ion binding
cytoplasmic microtubule organization
cytoskeletal protein binding
intermediate filament cytoskeleton organization
metal ion binding

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InterPro
Actinin-type actin-binding domain, conserved site
CH domain superfamily
Calponin homology domain
Desmoplakin, SH3 domain
Desmoplakin, spectrin-like domain
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain
GAR domain superfamily
GAR domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0112228	lissencephaly 9 with complex brainstem malformation	Alliance of Genome Resources
DOID:162	cancer	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11426		MGI:108559	MOUSE42049
Drosophila melanogaster	36542		FB:FBgn0013733
Caenorhabditis elegans	173058		WB:WBGene00006876
Rattus norvegicus	362587		RGD:1306057	RATNO33209
Pan troglodytes	456778	9598_0:00015e		PANTR20716
Canis lupus familiaris	475321			CANLF03927
Bos taurus	506730			BOVIN27246
Danio rerio	562190		ZFIN:ZDB-GENE-030131-3606
Macaca mulatta	718651			MACMU22436
Monodelphis domestica	100025003			MONDO22511

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements