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LEM domain containing 3

Summary

Gene Symbol

LEMD3

Organism

Homo sapiens (human)

External Links

NCBI Gene

23592

PubChem

23592

Alliance of Genome Resources

HGNC:28887

Annotation

Keyword

3D-structure
Acetylation
DNA-binding
Disease variant
Nucleus
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y2U8	LEM domain-containing protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
negative regulation of transforming growth factor beta receptor signaling pathway	IDA	15647271
negative regulation of BMP signaling pathway	IDA	15647271
negative regulation of activin receptor signaling pathway	IDA	15647271

GO Hierarchy

biological process

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nuclear inner membrane	IDA	15647271
nuclear membrane	IDA
membrane	IDA	10671519

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

organelle inner membrane [inference]

nuclear inner membrane

nuclear membrane

nuclear inner membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15231748 15647271 24407287 28514442 32296183 33961781
DNA binding	IEA
U1 snRNP binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

snRNP binding [inference]

U1 snRNP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Uncharacterized protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
chromatin DNA binding
nuclear envelope organization

Displaying **all 5** entries
InterPro
LEM domain
LEM/LEM-like domain superfamily
MAN1, winged-helix domain
Man1/Src1-like, C-terminal
Nucleotide-binding alpha-beta plait domain superfamily

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060688	arteriovenous malformations of the brain	Alliance of Genome Resources
DOID:0110243	cataract 46 juvenile-onset	Alliance of Genome Resources
DOID:0111536	Buschke-Ollendorff syndrome	Alliance of Genome Resources
DOID:11726	Emery-Dreifuss muscular dystrophy	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 75 in total

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Species	Gene ID	Orthologous MAtrix
Pteropus vampyrus	105301182	PTEVA03654
Macaca nemestrina	105473449	MACNE11222
Mandrillus leucophaeus	105537087	MANLE07538
Cercocebus atys	105600530	CERAT07985
Aotus nancymaae	105712017	AOTNA19218
Propithecus coquereli	105824185	PROCO15265
Dipodomys ordii	105989841	DIPOR01296
Equus asinus asinus	106829473	EQUAS16589
Sinocyclocheilus grahami	107561125	SINGR06238
Ictalurus punctatus	108279768	ICTPU12738