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phosphatidylserine decarboxylase

Summary

Gene Symbol

PISD

Aliases

PSDC
dJ858B16.2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23761

HGNC

8999

KEGG Gene ID

hsa:23761

PubChem

23761

Alliance of Genome Resources

HGNC:8999

Annotation

Keyword

Alternative splicing
Cataract
Cytoplasm
Deafness
Decarboxylase
Disease variant
Dwarfism
Intellectual disability
Lipid droplet
Mitochondrion inner membrane
Phospholipid biosynthesis
Pyruvate
Reference proteome
Transit peptide
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UG56

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lipid droplet formation	IMP	33593792
protein autoprocessing	IEA
mitochondrial protein catabolic process	IMP	30858161
phosphatidylethanolamine biosynthetic process	IBA IEA IMP	30488656 30858161
regulation of mitochondrion organization	IMP	30858161

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein catabolic process [inference]

mitochondrial protein catabolic process

protein maturation [inference]

protein processing [inference]

protein autoprocessing

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein catabolic process [inference]

mitochondrial protein catabolic process

protein maturation [inference]

protein processing [inference]

protein autoprocessing

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein catabolic process [inference]

mitochondrial protein catabolic process

protein maturation [inference]

protein processing [inference]

protein autoprocessing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein catabolic process [inference]

mitochondrial protein catabolic process

protein maturation [inference]

protein processing [inference]

protein autoprocessing

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

lipid droplet organization [inference]

lipid droplet formation

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of mitochondrion organization

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IDA
mitochondrial inner membrane	IEA
cytosol	IDA
lipid droplet	IEA
Golgi apparatus	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying 1 entry
GO Term	Evidence Code	PMID
phosphatidylserine decarboxylase activity	IBA IMP	30858161

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity [inference]

phosphatidylserine decarboxylase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000241878

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01613

Name

phosphatidylserine decarboxylase [EC:4.1.1.65]

References

Rhea

RHEA:20828

H⁺ + a 1,2-diacyl-sn-glycero-3-phospho-L-serine

CO₂ + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine

Enzyme

4.1.1.65

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 14 in total

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DO ID	Disease Name	Source
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:10907	microcephaly	DisGeNET
DOID:11165	common wart	DisGeNET
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:4450	renal cell carcinoma	DisGeNET
DOID:4451	renal carcinoma	DisGeNET
DOID:4464	collecting duct carcinoma	DisGeNET
DOID:4465	papillary renal cell carcinoma	DisGeNET
DOID:4467	clear cell renal cell carcinoma	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 12 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000407	Sensorineural hearing impairment
HP:0000543	Optic disc pallor
HP:0000546	Retinal degeneration
HP:0001249	Intellectual disability
HP:0001263	Global developmental delay
HP:0002650	Scoliosis
HP:0002663	Delayed epiphyseal ossification
HP:0004322	Short stature

Displaying 1 entry
Disease ID	Disease Name
OMIM:618889	Liberfarb syndrome

PubChem Disease

MedGen Diseases

Liberfarb syndrome

OMIM Phenotypes

LIBERFARB SYNDROME; LIBF

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006744
Gene Name: phosphatidylserine decarboxylase

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	176027	WB:WBGene00015159
Drosophila melanogaster	42849	FB:FBgn0026576
Petromyzon marinus	116939049		PETMA05459
Callorhinchus milii	103190198		CALMI43236
Latimeria chalumnae	102352075		LATCH19570
Lepisosteus oculatus	102698858		LEPOC07962
Danio rerio	553433	ZFIN:ZDB-GENE-061215-46	DANRE35823
Electrophorus electricus	113572483		ELEEL12143
Esox lucius	105015134		ESOLU43207
Salmo salar	100380321		SALSA13275

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements