GlyCosmos Portal

Submissions

gremlin 2, DAN family BMP antagonist

Summary

Gene Symbol

Grem2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

23893

PubChem

23893

Alliance of Genome Resources

MGI:1344367

Annotation

Keyword

3D-structure
Cytokine
Developmental protein
Disulfide bond
Glycoprotein
Heparin-binding
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3TST1
O88273	Cysteine knot superfamily 1, BMP antagonist 2 Protein related to DAN and cerberus

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
regulation of cytokine activity	IMP	23850456
cytokine-mediated signaling pathway	IMP	23850456
embryonic body morphogenesis	IMP	23850456
negative regulation of BMP signaling pathway	IMP	23063586
animal organ morphogenesis

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation [inference]

determination of dorsal identity

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

body morphogenesis [inference]

embryonic body morphogenesis

embryonic morphogenesis [inference]

embryonic body morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of binding [inference]

regulation of protein binding [inference]

regulation of receptor binding [inference]

regulation of cytokine activity

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular space	IBA IMP	23063586

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying **all 5** entries
GO Term	Evidence Code	PMID
heparin binding	IDA	23850456
receptor ligand activity	IBA
identical protein binding	IMP IPI	23063586 23850456
BMP binding	IBA IMP	23063586
cytokine activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity

cytokine activity

cytokine binding [inference]

BMP binding

identical protein binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050591	tooth agenesis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 73 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	64388	HGNC:17655	HUMAN55411
Caenorhabditis elegans	179595	WB:WBGene00009389
Rattus norvegicus	289264	RGD:1560008	RATNO06949
Pan troglodytes	469727		PANTR24021
Canis lupus familiaris	490367		CANLF17301
Danio rerio	550399	ZFIN:ZDB-GENE-030911-9	DANRE04437
Macaca mulatta	708280		MACMU21584
Danio rerio	100002201	ZFIN:ZDB-GENE-131127-498
Monodelphis domestica	100020610		MONDO11832
Equus caballus	100060243		HORSE29290