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beta galactoside alpha 2,6 sialyltransferase 2

Summary

Gene Symbol

St6gal2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

240119

KEGG Gene ID

mmu:240119

PubChem

240119

Alliance of Genome Resources

MGI:2445190

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q76K27	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2 ST6Gal II Sialyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
N-acetylneuraminate metabolic process	IC	12603328
oligosaccharide metabolic process	ISO
sialylation	IBA
protein glycosylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

N-acetylneuraminate metabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

sialylation

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

N-acetylneuraminate metabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA
Golgi apparatus	IBA
Golgi cisterna membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

Golgi cisterna membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glycosyltransferase activity	IEA
beta-galactoside alpha-2,6-sialyltransferase activity	IBA ISO	12603328
transferase activity	IEA
sialyltransferase activity	IDA	12966079

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

glycosyltransferase activity

sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00779

Name

beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2) [EC:2.4.3.1]

References

12235148

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R06188	2.4.3.1	G51331BY	G09376MR

Rhea

RHEA:21552

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + CMP

Enzyme

2.4.3.1

PMID

2460092

RHEA:11836

N-acetyl-β-lactosamine + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine + CMP

Enzyme

2.4.3.1

PMID

RHEA:52104

a β-D-galactoside + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl derivative + H⁺ + CMP

Enzyme

2.4.3.1

PMID

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	37950	FB:FBgn0035050
Callorhinchus milii	103172241		CALMI05394
Latimeria chalumnae	102359235		LATCH12158
Danio rerio	403116	ZFIN:ZDB-GENE-060322-4
Danio rerio	797439	ZFIN:ZDB-GENE-120426-2
Xenopus tropicalis	407846	Xenbase:XB-GENE-990439
Chrysemys picta bellii	101950728		CHRPI32195
Crocodylus porosus	109306264		CROPO03424
Pseudonaja textilis	113440840		PSETE12593
Meleagris gallopavo	100545097		MELGA01544

GlyTouCan

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GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements