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ADAM metallopeptidase with thrombospondin type 1 motif 19

Summary

Gene Symbol

Adamts19

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

240322

PubChem

240322

Alliance of Genome Resources

MGI:2442875

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P59509

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
aortic valve morphogenesis	ISO
aortic valve morphogenesis	IMP	31844321
mitral valve morphogenesis	ISO
pulmonary valve morphogenesis	ISO
tricuspid valve morphogenesis	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

developmental process [inference]

anatomical structure morphogenesis [inference]

heart valve morphogenesis [inference]

aortic valve morphogenesis

atrioventricular valve morphogenesis [inference]

pulmonary valve morphogenesis

cardiac septum morphogenesis [inference]

ventricular septum morphogenesis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

Displaying **all 3** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

thrombospondin

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
extracellular matrix organization
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
ADAMTS, cysteine-rich domain 2
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:62	aortic valve disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	11173	FB:FBgn0029791
Drosophila melanogaster	81792	FB:FBgn0029791
Drosophila melanogaster	108153	FB:FBgn0029791
Drosophila melanogaster	170691	FB:FBgn0029791
Drosophila melanogaster	170692	FB:FBgn0029791
Homo sapiens	171019	Xenbase:XB-GENE-980450	HUMAN80568
Drosophila melanogaster	208936	FB:FBgn0029791
Drosophila melanogaster	239337	FB:FBgn0029791
Xenopus tropicalis	240322	Xenbase:XB-GENE-980450
Drosophila melanogaster	315879	FB:FBgn0029791

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements