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kinesin family member 4A

Summary

Gene Symbol

KIF4A

Organism

Homo sapiens (human)

External Links

NCBI Gene

24137

PubChem

24137

Alliance of Genome Resources

HGNC:13339

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Chromosome
Coiled coil
Cytoskeleton
DNA-binding
Intellectual disability
Iron-sulfur
Isopeptide bond
Microtubule
Motor protein
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O95239	Chromokinesin-A
Q59HG1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
mitotic cytokinesis	IMP	15843429
spindle elongation	IBA
anterograde axonal transport	TAS	7929562
mitotic spindle midzone assembly	IMP	15843429
mitotic spindle organization	IBA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

spindle elongation

spindle midzone assembly [inference]

mitotic spindle midzone assembly

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

spindle organization [inference]

mitotic spindle organization

spindle elongation

spindle midzone assembly [inference]

mitotic spindle midzone assembly

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

cellular component assembly [inference]

spindle midzone assembly [inference]

mitotic spindle midzone assembly

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

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GO Term	Evidence Code	PMID
microtubule associated complex	IBA
membrane	HDA	19946888
midbody	IDA	15166316
nuclear matrix	IEA
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex

cellular anatomical entity [inference]

nucleoplasm

cytoplasm

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

axon cytoplasm

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

spindle microtubule

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GO Term	Evidence Code	PMID
protein binding	IPI	16431929 28160558
DNA binding	IEA
metal ion binding	IEA
microtubule binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kinesin

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
cytoskeletal motor activity
microtubule binding
microtubule-based movement
nucleotide binding

Displaying **all 5** entries
InterPro
Kinesin motor domain superfamily
Kinesin motor domain, conserved site
Kinesin motor domain
Kinesin-like protein
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0112040	non-syndromic X-linked intellectual disability 100	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16571	MGI:108389	MOUSE66588
Drosophila melanogaster	31240	FB:FBgn0011606
Rattus norvegicus	84393	RGD:620526	RATNO44310
Caenorhabditis elegans	176750	WB:WBGene00002229
Danio rerio	393796	ZFIN:ZDB-GENE-040426-1545	DANRE20418
Xenopus laevis	394332	Xenbase:XB-GENE-6079277
Xenopus tropicalis	448410	Xenbase:XB-GENE-5932310
Canis lupus familiaris	491941		CANLF19863
Bos taurus	537127		BOVIN36933
Macaca mulatta	695574		MACMU48062

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Annotation

OrthoDB (Group)

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Acknowledgements