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cytochrome P450, family 1, subfamily a, polypeptide 2

Summary

Gene Symbol

Cyp1a2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24297

PubChem

24297

Alliance of Genome Resources

RGD:2459

Annotation

Keyword

Direct protein sequencing
Fatty acid metabolism
Glycoprotein
Heme
Lyase
Membrane
Microsome
Monooxygenase
Reference proteome
Sterol metabolism

Proteins

Displaying 1 entry
UniProt	Protein Name
P04799	CYPIA2 Cholesterol 25-hydroxylase Cytochrome P-448 Cytochrome P-450d Cytochrome P450-D Hydroperoxy icosatetraenoate dehydratase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
response to immobilization stress	IEP	17973897
cholesterol metabolic process	IEA
response to organic cyclic compound	IEP	18754104
dibenzo-p-dioxin metabolic process	IEA ISO
hydrogen peroxide biosynthetic process	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

nitroglycerin metabolic process

organonitrogen compound metabolic process [inference]

alkaloid metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

catabolic process [inference]

cellular catabolic process [inference]

xenobiotic catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

secondary metabolite biosynthetic process [inference]

toxin biosynthetic process

organic substance biosynthetic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

secondary metabolic process [inference]

toxin metabolic process

toxin biosynthetic process

secondary metabolite biosynthetic process [inference]

toxin biosynthetic process

hormone metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

cellular aromatic compound metabolic process [inference]

dibenzo-p-dioxin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

xenobiotic metabolic process

toxin metabolic process

toxin biosynthetic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

heterocycle metabolic process [inference]

dibenzo-p-dioxin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

vitamin E metabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid catabolic process [inference]

steroid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

vitamin metabolic process [inference]

fat-soluble vitamin metabolic process [inference]

vitamin E metabolic process

dibenzo-p-dioxin metabolic process

demethylation [inference]

oxidative demethylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid catabolic process [inference]

steroid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

nitroglycerin metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

olefinic compound metabolic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

dibenzo-p-dioxin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

vitamin E metabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

organonitrogen compound metabolic process [inference]

alkaloid metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

organic substance biosynthetic process [inference]

hydrogen peroxide biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

vitamin E metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

cellular aromatic compound metabolic process [inference]

dibenzo-p-dioxin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

xenobiotic metabolic process

toxin metabolic process

toxin biosynthetic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

heterocycle metabolic process [inference]

dibenzo-p-dioxin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

vitamin E metabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

multicellular organismal process [inference]

post-embryonic development

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

lung development

response to stimulus [inference]

response to stress [inference]

response to immobilization stress

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin E

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin E

response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to organic cyclic compound

response to lipid [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to cadmium ion [inference]

cellular response to cadmium ion

response to copper ion [inference]

cellular response to copper ion

cellular response to metal ion [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

response to nitrogen compound [inference]

response to nitroglycerin

response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA
intracellular membrane-bounded organelle	IBA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

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GO Term	Evidence Code	PMID
demethylase activity	IEA ISO
lyase activity	IEA
oxidoreductase activity	ISO
caffeine oxidase activity	IEA ISO
aromatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

steroid hydroxylase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

oxidoreductase activity, acting on other nitrogenous compounds as donors [inference]

oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [inference]

nitrite reductase (NO-forming) activity

nitrite reductase activity [inference]

nitrite reductase (NO-forming) activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

oxidoreductase activity, acting on CH or CH2 groups [inference]

oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor [inference]

caffeine oxidase activity

lyase activity

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

hydroperoxy icosatetraenoate dehydratase activity

demethylase activity

binding [inference]

protein binding [inference]

enzyme binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Cytochrome P450

Functional Category

K: Transcription
L: Replication, recombination and repair
Q: Secondary metabolites biosynthesis, transport and catabolism
V: Defense mechanisms

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Gene Ontology
17-alpha-hydroxyprogesterone aldolase activity
aromatase activity
heme binding
hormone biosynthetic process
hydroperoxy icosatetraenoate dehydratase activity
iron ion binding
lipid metabolic process
lyase activity
metal ion binding
monooxygenase activity

Displaying **all 5** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I, CYP1
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources
DOID:3132	porphyria cutanea tarda	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1544		HGNC:2596	HUMAN24203
Mus musculus	13077	10090_1:002e41	MGI:88589	MOUSE61919
Danio rerio	140634		ZFIN:ZDB-GENE-011219-1	DANRE14017
Canis lupus familiaris	494010			CANLF12699
Bos taurus	503552			BOVIN16654
Felis catus	554345			FELCA14718
Pan troglodytes	735881			PANTR10805
Xenopus tropicalis	100037911		Xenbase:XB-GENE-990173
Equus caballus	100062244			HORSE17226
Oryzias latipes	100125806			ORYLA12681

GlyTouCan

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements