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kallikrein 1

Summary

Gene Symbol

Klk1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24523

PubChem

24523

Alliance of Genome Resources

RGD:2969

Annotation

Keyword

Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Serine protease
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P36373	Esterase B Kallikrein-related protein K1 Proteinase A RSKG-7 Tissue kallikrein
G3V8H1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
proteolysis	IEA
zymogen activation
positive regulation of antibacterial peptide production
positive regulation of cell population proliferation	IMP	17473535
positive regulation of acute inflammatory response	IMP	17015177

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to chemical [inference]

response to nutrient

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
epidermal lamellar body
nucleus	ISO
extracellular space
cornified envelope
acrosomal vesicle	IDA	12558526

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane [inference]

cornified envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

acrosomal vesicle

lamellar body [inference]

epidermal lamellar body

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

acrosomal vesicle

lamellar body [inference]

epidermal lamellar body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

acrosomal vesicle

lamellar body [inference]

epidermal lamellar body

apical part of cell

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endopeptidase activity	IDA	16231010
peptidase activity
serine-type endopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
acrosomal vesicle	PMID:12558526
apical part of cell	PMID:12558526

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:4989	pancreatitis	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources

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LM-GlycoRepo

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Acknowledgements