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mono-ADP ribosylhydrolase 1

Summary

Gene Symbol

Macrod1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

246233

PubChem

246233

Alliance of Genome Resources

RGD:628701

Annotation

Keyword

Acetylation
DNA damage
Hydrolase
Isopeptide bond
Nucleus
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8K4G6	MACRO domain-containing protein 1 O-acetyl-ADP-ribose deacetylase MACROD1 Protein LRP16 [Protein ADP-ribosylaspartate] hydrolase MACROD1 [Protein ADP-ribosylglutamate] hydrolase MACROD1
A0A8I6AN55

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
biological_process	ND
purine nucleoside metabolic process	IBA IEA ISO
peptidyl-glutamate ADP-deribosylation	IBA
cellular response to DNA damage stimulus	IBA IEA ISO ISS
protein de-ADP-ribosylation

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

macromolecule modification [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleus	ISO ISS
nucleoplasm	IBA IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
hydrolase activity, acting on glycosyl bonds	ISO ISS
ADP-ribosylglutamate hydrolase activity	IBA IEA ISO ISS
deacetylase activity	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

ADP-ribosylglutamate hydrolase activity

deacetylase activity

catalytic activity, acting on a protein [inference]

ADP-ribosylglutamate hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:59244

3''-O-acetyl-ADP-D-ribose + H₂O

H⁺ + acetate + ADP-D-ribose

Enzyme

3.1.1.106

PMID

RHEA:57060

H₂O + 2''-O-acetyl-ADP-D-ribose

H⁺ + acetate + ADP-D-ribose

Enzyme

3.1.1.106

PMID

Ortholog

Displaying entries **11 - 20** of 42 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Macaca mulatta	717961		MACMU11621
Macaca nemestrina	105469499		MACNE28831
Papio anubis	101021555		PAPAN05640
Gorilla gorilla gorilla	101145140		GORGO03632
Pan troglodytes	451285		PANTR03250
Pongo abelii	100433052		PONAB02666
Homo sapiens	28992	HGNC:29598	HUMAN06799
Felis catus	101091478		FELCA25021
Panthera leo	122199332		PANLE14573
Balaenoptera musculus	118899171		BALMU09479