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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
interleukin 27
Summary
- Gene Symbol
-
- Il27
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- 3D-structure
- Cytokine
- Glycoprotein
- Inflammatory response
- Innate immunity
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| Q8K3I6 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of defense response to virus by host | ||
| regulation of T cell proliferation | ||
| positive regulation of type II interferon production | ||
| innate immune response | ||
| regulation of T-helper 1 cell differentiation |
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
positive regulation of biological process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| cell surface | ||
| extracellular space | ||
| cytosol |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| signaling receptor binding | ||
| cytokine activity | ||
| interleukin-27 receptor binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- interleukin-27 subunit alpha
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| interleukin-27 receptor binding |
| regulation of T cell proliferation |
| regulation of T-helper 1 cell differentiation |
| InterPro |
|---|
| Four-helical cytokine-like, core |
| Interleukin-27 alpha |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:106 | pleural tuberculosis | |
| DOID:10887 | lepromatous leprosy | |
| DOID:11123 | Henoch-Schoenlein purpura | |
| DOID:1724 | duodenal ulcer | |
| DOID:2043 | hepatitis B | |
| DOID:2841 | asthma | |
| DOID:2957 | pulmonary tuberculosis | |
| DOID:3083 | chronic obstructive pulmonary disease | |
| DOID:321 | tropical spastic paraparesis | |
| DOID:399 | tuberculosis |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 246778 | HGNC:19157 | HUMAN27469 | ||
| 365368 | 10116_1:000ba1 | RGD:1561420 | RATNO20553 | |
| 493187 | PIGXX20667 | |||
| 614927 | BOVIN20531 | |||
| 708678 | MACMU27630 | |||
| 100014555 | MONDO29232 | |||
| 100472637 | AILME04454 | |||
| 100605770 | NOMLE25305 | |||
| 100657097 | LOXAF05501 | |||
| 100724612 | 10141_0:004673 | CAVPO03212 |
