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steroid sulfatase

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24800

PubChem

24800

Alliance of Genome Resources

RGD:3783

Annotation

Keyword

Calcium
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Microsome
Pregnancy
Reference proteome
Signal
Steroid metabolism
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
G3V9E5
P15589	Arylsulfatase C Steroid sulfatase Steryl-sulfate sulfohydrolase
A6IPT8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
female pregnancy	IEA
learning or memory	IMP	10821934
steroid metabolic process	IEA
positive regulation of cell population proliferation	IMP	17268815
response to pH	IDA	6586719

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

multi-multicellular organism process [inference]

female pregnancy

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

skin development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to pH

response to endogenous stimulus [inference]

response to hormone [inference]

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to organic cyclic compound

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nuclear envelope	IDA	2703703
endoplasmic reticulum membrane	IDA	2703703

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

Displaying **all 5** entries
GO Term	Evidence Code	PMID
arylsulfatase activity	IBA
steryl-sulfatase activity	IDA	8662223
sulfuric ester hydrolase activity	ISO
hydrolase activity	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

sulfuric ester hydrolase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

arylsulfatase i

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
sulfuric ester hydrolase activity

Displaying **all 3** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
Sulfatase, N-terminal
Sulfatase, conserved site

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
nuclear envelope	PMID:2703703
endoplasmic reticulum membrane	PMID:2703703

Rhea

RHEA:19873

H₂O + dehydroepiandrosterone 3-sulfate

H⁺ + sulfate + 3β-hydroxyandrost-5-en-17-one

Enzyme

3.1.6.2

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012436
Gene Name: steroid sulfatase (microsomal), isozyme S

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	410	WB:WBGene00006309
Homo sapiens	412	Xenbase:XB-GENE-1013410	HUMAN99647
Caenorhabditis elegans	414	WB:WBGene00006309
Caenorhabditis elegans	415	WB:WBGene00006309
Caenorhabditis elegans	416	WB:WBGene00006309
Caenorhabditis elegans	2588	WB:WBGene00006309
Caenorhabditis elegans	11883	WB:WBGene00006309
Xenopus tropicalis	20905	Xenbase:XB-GENE-1013410
Xenopus tropicalis	24800	Xenbase:XB-GENE-1013410
Caenorhabditis elegans	50917	WB:WBGene00006309

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements