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Submissions

UDP glucuronosyltransferase family 1 member A1

Summary

Gene Symbol

Ugt1a1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24861

KEGG Gene ID

rno:24861

PubChem

24861

Alliance of Genome Resources

RGD:3935

Annotation

Keyword

Alternative splicing
Direct protein sequencing
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Lipid metabolism
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q64550	B1 UDP-glucuronosyltransferase 1-1
Q5DT04
Q547Q8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
cellular response to ethanol	IEP	11412396
response to ethanol	IEP	11848303
response to organic cyclic compound	IEP	11854140
animal organ regeneration	IEP	16222444
flavone metabolic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

biphenyl catabolic process

xenobiotic catabolic process [inference]

biphenyl catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

biphenyl catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

pigment metabolic process [inference]

flavone metabolic process

hormone metabolic process [inference]

estrogen metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

biphenyl catabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

benzene-containing compound metabolic process [inference]

biphenyl metabolic process [inference]

biphenyl catabolic process

xenobiotic metabolic process [inference]

xenobiotic catabolic process [inference]

biphenyl catabolic process

xenobiotic glucuronidation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

biphenyl catabolic process

xenobiotic catabolic process [inference]

biphenyl catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

lipid metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

flavonoid metabolic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

benzene-containing compound metabolic process [inference]

biphenyl metabolic process [inference]

biphenyl catabolic process

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

biphenyl catabolic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

biphenyl catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

biphenyl catabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

benzene-containing compound metabolic process [inference]

biphenyl metabolic process [inference]

biphenyl catabolic process

xenobiotic metabolic process [inference]

xenobiotic catabolic process [inference]

biphenyl catabolic process

xenobiotic glucuronidation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

biphenyl catabolic process

xenobiotic catabolic process [inference]

biphenyl catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

bilirubin conjugation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to estradiol stimulus

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

cellular response to alcohol [inference]

cellular response to ethanol

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

animal organ regeneration

gland development [inference]

liver development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

acute-phase response

response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

response to steroid hormone

response to corticosteroid [inference]

response to glucocorticoid

cellular response to glucocorticoid stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

response to chemical [inference]

response to nutrient

response to xenobiotic stimulus

cellular response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

cellular response to hormone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

response to steroid hormone

response to corticosteroid [inference]

response to glucocorticoid

cellular response to glucocorticoid stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

response to organic cyclic compound

response to estradiol [inference]

cellular response to estradiol stimulus

response to steroid hormone

response to corticosteroid [inference]

response to glucocorticoid

cellular response to glucocorticoid stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to estradiol stimulus

response to lipid [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

response to lipopolysaccharide

response to steroid hormone

response to corticosteroid [inference]

response to glucocorticoid

cellular response to glucocorticoid stimulus

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to estradiol stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to estradiol stimulus

cellular response to alcohol [inference]

cellular response to ethanol

response to alcohol [inference]

response to ethanol

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to estradiol stimulus

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

cellular response to alcohol [inference]

cellular response to ethanol

response to oxygen-containing compound [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

response to lipopolysaccharide

response to alcohol [inference]

response to ethanol

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus [inference]

cellular response to corticosteroid stimulus [inference]

cellular response to glucocorticoid stimulus

cellular response to estradiol stimulus

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

cellular response to alcohol [inference]

cellular response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular glucuronidation

negative regulation of carbohydrate metabolic process [inference]

negative regulation of cellular glucuronidation

negative regulation of small molecule metabolic process [inference]

negative regulation of cellular glucuronidation

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular glucuronidation

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

negative regulation of small molecule metabolic process [inference]

negative regulation of cellular glucuronidation

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

negative regulation of carbohydrate metabolic process [inference]

negative regulation of cellular glucuronidation

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular glucuronidation

negative regulation of carbohydrate metabolic process [inference]

negative regulation of cellular glucuronidation

negative regulation of small molecule metabolic process [inference]

negative regulation of cellular glucuronidation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular glucuronidation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular glucuronidation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular glucuronidation

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

estrogen metabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA IDA ISO	14561759
plasma membrane	ISO
cytochrome complex	IDA	17965520
endoplasmic reticulum chaperone complex	ISO
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

endoplasmic reticulum protein-containing complex [inference]

endoplasmic reticulum chaperone complex

catalytic complex [inference]

cytochrome complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein heterodimerization activity	ISO
glucuronosyltransferase activity	IDA ISO	11829457
enzyme inhibitor activity	ISO
retinoic acid binding	ISO
enzyme binding	IBA IDA ISO	17965520

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

glucuronosyltransferase activity

hexosyltransferase activity [inference]

glucuronosyltransferase activity

binding [inference]

protein binding [inference]

enzyme binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

lipid binding [inference]

steroid binding

isoprenoid binding [inference]

retinoid binding [inference]

retinoic acid binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

organic cyclic compound binding [inference]

steroid binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00699

Name

glucuronosyltransferase [EC:2.4.1.17]

References

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cytochrome complex	PMID:17965520

Rhea

RHEA:21032

glucuronate acceptor + UDP-α-D-glucuronate

acceptor β-D-glucuronoside + H⁺ + UDP

Enzyme

2.4.1.17

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:10211	cholelithiasis	Alliance of Genome Resources
DOID:11151	cholecystolithiasis	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:2043	hepatitis B	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources
DOID:2739	Gilbert syndrome	Alliance of Genome Resources
DOID:2741	bilirubin metabolic disorder	Alliance of Genome Resources
DOID:3803	Crigler-Najjar syndrome	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012443
Gene Name: UDP glucuronosyltransferase 1 family, polypeptide A1

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements