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cholecystokinin A receptor

Summary

Gene Symbol

Cckar

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24889

PubChem

24889

Alliance of Genome Resources

RGD:2289

Annotation

Keyword

Cell membrane
Direct protein sequencing
Disulfide bond
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P30551	Cholecystokinin-1 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
temperature homeostasis	IMP	15178543
gastric acid secretion	IDA	9773935
neuron migration	ISO
neuron migration	IEA
reduction of food intake in response to dietary excess	IMP	12840200

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

cholecystokinin signaling pathway

cell motility [inference]

cell migration [inference]

neuron migration

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

gastric acid secretion

behavior [inference]

feeding behavior

eating behavior

reduction of food intake in response to dietary excess

multicellular organismal-level homeostasis [inference]

temperature homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

anatomical structure development [inference]

forebrain development

regeneration [inference]

animal organ regeneration

animal organ development [inference]

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

response to stimulus [inference]

response to stress [inference]

response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

response to steroid hormone

response to corticosteroid [inference]

response to glucocorticoid

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

response to chemical [inference]

response to nutrient

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

cellular response to hormone stimulus

response to steroid hormone

response to corticosteroid [inference]

response to glucocorticoid

response to organic cyclic compound [inference]

response to steroid hormone

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone

response to corticosteroid [inference]

response to glucocorticoid

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

response to oxygen-containing compound [inference]

response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

acid secretion [inference]

gastric acid secretion

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of hormone secretion

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of peptide hormone secretion [inference]

regulation of somatostatin secretion [inference]

positive regulation of somatostatin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of peptide hormone secretion [inference]

regulation of somatostatin secretion [inference]

positive regulation of somatostatin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of peptide hormone secretion [inference]

regulation of somatostatin secretion [inference]

positive regulation of somatostatin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of peptide hormone secretion [inference]

regulation of somatostatin secretion [inference]

positive regulation of somatostatin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

cholecystokinin signaling pathway

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of hormone secretion

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of peptide hormone secretion [inference]

regulation of somatostatin secretion [inference]

positive regulation of somatostatin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of peptide hormone secretion [inference]

regulation of somatostatin secretion [inference]

positive regulation of somatostatin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

regulation of hormone secretion

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

regulation of peptide hormone secretion [inference]

regulation of somatostatin secretion [inference]

positive regulation of somatostatin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of somatostatin secretion

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
endosome	IDA	9169450
cytosol	ISO
cytosol	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

presynapse [inference]

terminal bouton

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cholecystokinin receptor activity	ISO
cholecystokinin receptor activity	TAS	1528881
cholecystokinin receptor activity	IDA	18776046
cholecystokinin receptor activity	IBA
cholecystokinin receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

amide binding [inference]

peptide binding

peptide hormone binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

cholecystokinin receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

cholecystokinin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
endosome	PMID:9169450
terminal bouton	PMID:3408996

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **108** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	886	Xenbase:XB-GENE-992615	HUMAN75167
Drosophila melanogaster	887	FB:FBgn0030954
Mus musculus	12425	Xenbase:XB-GENE-992615	MOUSE45799
Drosophila melanogaster	12426	FB:FBgn0030954
Xenopus tropicalis	24889	Xenbase:XB-GENE-992615
Drosophila melanogaster	25706	FB:FBgn0030954
Pan troglodytes	471163		PANTR33454
Canis lupus familiaris	488846		CANLF12283
Danio rerio	569038		DANRE41866
Macaca mulatta	694742		MACMU36789

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements