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ATP binding cassette subfamily B member 4

Summary

Gene Symbol

Abcb4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24891

PubChem

24891

Alliance of Genome Resources

RGD:620248

Annotation

Keyword

ATP-binding
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Glycoprotein
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q08201	ATP-binding cassette sub-family B member 4 Multidrug resistance protein 2 Multidrug resistance protein 3 P-glycoprotein 2 P-glycoprotein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
phospholipid translocation	IBA IEA ISO
response to xenobiotic stimulus	IEP	10464145
cellular response to bile acid	IEA ISO ISS
xenobiotic transmembrane transport	ISO
positive regulation of cholesterol transport	IEA ISO ISS

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

transmembrane transport

xenobiotic transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

response to fenofibrate

response to bile acid [inference]

cellular response to bile acid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to lipid [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

response to ether [inference]

response to fenofibrate

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

response to ketone [inference]

response to fenofibrate

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to oxygen-containing compound [inference]

response to ether [inference]

response to fenofibrate

response to ketone [inference]

response to fenofibrate

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

localization [inference]

establishment of localization [inference]

transport [inference]

xenobiotic transport [inference]

xenobiotic transmembrane transport

secretion [inference]

acid secretion [inference]

bile acid secretion

transmembrane transport

xenobiotic transmembrane transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport [inference]

phospholipid translocation

lipid translocation [inference]

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

ceramide transport [inference]

ceramide translocation

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid secretion

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid translocation

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid secretion

nitrogen compound transport [inference]

amide transport [inference]

ceramide transport [inference]

ceramide translocation

sphingolipid translocation [inference]

ceramide translocation

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
apical plasma membrane	IBA IDA IEA ISO	10748167
clathrin-coated vesicle	IEA
cytoplasm	ISO
plasma membrane	ISO
nucleoplasm	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

apical plasma membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

intercellular canaliculus

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
ABC-type transporter activity	IEA
phosphatidylcholine floppase activity	IBA IEA ISO ISS
ATP binding	IEA
ATPase-coupled transmembrane transporter activity	IBA ISO ISS
ceramide floppase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

phosphatidylcholine transporter activity [inference]

phosphatidylcholine floppase activity

sphingolipid transporter activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity [inference]

floppase activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ATPase-coupled intramembrane lipid transporter activity [inference]

floppase activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
apical plasma membrane	PMID:10748167
Golgi membrane	PMID:10748167

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0060643	primary sclerosing cholangitis	Alliance of Genome Resources
DOID:0070223	progressive familial intrahepatic cholestasis 3	Alliance of Genome Resources
DOID:0070229	intrahepatic cholestasis of pregnancy 3	Alliance of Genome Resources
DOID:12236	primary biliary cholangitis	Alliance of Genome Resources
DOID:13580	cholestasis	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:1852	intrahepatic cholestasis	Alliance of Genome Resources
DOID:1949	cholecystitis	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

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