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Guidelines

MIRAGE

lysosomal-associated membrane protein 2

Summary

Gene Symbol

Lamp2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24944

PubChem

24944

Alliance of Genome Resources

RGD:2990

Annotation

Keyword

Autophagy
Cell membrane
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Endosome
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P17046	CD107 antigen-like family member B LGP-110 LGP-96 Lysosomal membrane glycoprotein type B
A0A8I6AMZ0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
protein targeting	ISS
protein targeting	ISO
autophagy	ISO
lysosomal lumen acidification	ISS
lysosomal lumen acidification	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

catabolic process [inference]

cellular catabolic process [inference]

chaperone-mediated autophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

chaperone-mediated autophagy

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

protein metabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular metabolic process [inference]

cellular catabolic process [inference]

chaperone-mediated autophagy

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization [inference]

protein targeting

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

process utilizing autophagic mechanism [inference]

chaperone-mediated autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization [inference]

protein targeting

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of localization [inference]

establishment of protein localization [inference]

protein targeting

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization [inference]

protein targeting

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of biological quality [inference]

regulation of protein stability

protein stabilization

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	PMID
autophagosome membrane	ISO
autophagosome membrane	IBA
autophagosome membrane	IEA
extracellular space	ISO
lysosome	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

chaperone-mediated autophagy translocation complex

cellular anatomical entity [inference]

extracellular space

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane [inference]

platelet dense granule membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

autophagosome membrane

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

late endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane [inference]

platelet dense granule membrane

membrane microdomain [inference]

membrane raft

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

secondary lysosome [inference]

autolysosome

autophagosome [inference]

autolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

secondary lysosome [inference]

autolysosome

autophagosome [inference]

autolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
protein binding	IPI	12505983 18644871
ion channel inhibitor activity	ISS
ion channel inhibitor activity	ISO
ion channel inhibitor activity	IEA
enzyme binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity

ion channel regulator activity [inference]

ion channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Lysosome-associated membrane glycoprotein

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
establishment of protein localization to organelle

Displaying **all 3** entries
InterPro
Lysosome-associated membrane glycoprotein 2-like, luminal domains
Lysosome-associated membrane glycoprotein 2-like, transmembrane domain
Lysosome-associated membrane glycoprotein

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
endosome	PMID:16085051

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0050437	Danon disease	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:13580	cholestasis	Alliance of Genome Resources
DOID:1561	cognitive disorder	Alliance of Genome Resources
DOID:2475	chronic conjunctivitis	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3916	FB:FBgn0032949
Homo sapiens	3920	Xenbase:XB-GENE-962456	HUMAN102021
Drosophila melanogaster	16783	FB:FBgn0032949
Mus musculus	16784	Xenbase:XB-GENE-962456	MOUSE64929
Xenopus tropicalis	24944	Xenbase:XB-GENE-962456
Drosophila melanogaster	25328	FB:FBgn0032949
Homo sapiens	180912	HGNC:6501
Canis lupus familiaris	481037		CANLF20116
Bos taurus	529148		BOVIN36243
Macaca mulatta	695379		MACMU47599

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Last updated: August 4, 2025