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fibroblast growth factor receptor 2
Summary
- Gene Symbol
-
- Fgfr2
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- ATP-binding
- Cell membrane
- Disulfide bond
- Glycoprotein
- Immunoglobulin domain
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| mammary gland bud formation | ||
| positive regulation of cell population proliferation | ||
| prostate epithelial cord elongation | ||
| membranous septum morphogenesis | ||
| cellular response to fibroblast growth factor stimulus |
GO Hierarchy
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification
- fibroblast growth factor receptor apoptotic signaling pathway
- synaptic vesicle transport
- membranous septum morphogenesis
- hair follicle morphogenesis
- lung lobe morphogenesis
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification
- fibroblast growth factor receptor apoptotic signaling pathway
biological process
metabolic process [inference]
cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway
fibroblast growth factor receptor signaling pathway
reproductive process [inference]
multicellular organismal process [inference]
developmental process [inference]
developmental process involved in reproduction [inference]
anatomical structure morphogenesis [inference]
morphogenesis of a branching structure [inference]
tissue morphogenesis [inference]
anatomical structure development [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of growth [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway
fibroblast growth factor receptor signaling pathway
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi apparatus | ||
| cell cortex | ||
| receptor complex | ||
| collagen-containing extracellular matrix | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| fibroblast growth factor binding | ||
| identical protein binding | ||
| ATP binding | ||
| protein homodimerization activity | ||
| fibroblast growth factor receptor activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- fibroblast growth factor receptor 2 isoform a
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1612 | breast cancer | |
| DOID:1749 | squamous cell carcinoma | |
| DOID:224 | transient cerebral ischemia | |
| DOID:2339 | Crouzon syndrome | |
| DOID:2340 | craniosynostosis | |
| DOID:2671 | transitional cell carcinoma | |
| DOID:289 | endometriosis | |
| DOID:3070 | high grade glioma | |
| DOID:4441 | dysgerminoma | |
| DOID:5517 | stomach carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 2263 | HGNC:3689 | HUMAN03196 | ||
| 14183 | 10090_1:002699 | MGI:95523 | MOUSE55131 | |
| 39564 | FB:FBgn0285896 | |||
| 42160 | FB:FBgn0010389 | |||
| 352940 | ZFIN:ZDB-GENE-030323-1 | |||
| 396762 | PIGXX08612 | |||
| 404193 | BOVIN21662 | |||
| 415125 | CANLF11534 | |||
| 443548 | SHEEP11666 | |||
| 466220 | PANTR01695 |
