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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
protein C, inactivator of coagulation factors Va and VIIIa
Summary
- Gene Symbol
-
- Proc
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Blood coagulation
- Calcium
- Cleavage on pair of basic residues
- Disulfide bond
- EGF-like domain
- Endoplasmic reticulum
- Gamma-carboxyglutamic acid
- Glycoprotein
- Golgi apparatus
- Hydroxylation
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Zymogen
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| negative regulation of coagulation | ||
| positive regulation of establishment of endothelial barrier | ||
| negative regulation of inflammatory response | ||
| negative regulation of blood coagulation |
GO Hierarchy
biological process
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi apparatus | ||
| endoplasmic reticulum | ||
| extracellular space |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| identical protein binding | ||
| oligopeptidase activity | ||
| peptidase activity | ||
| calcium ion binding | ||
| serine-type endopeptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- vitamin K-dependent protein C
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- O: Posttranslational modification, protein turnover, chaperones
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060903 | thrombosis | |
| DOID:0111902 | thrombophilia due to activated protein C resistance | |
| DOID:0111904 | autosomal recessive thrombophilia due to protein C deficiency | |
| DOID:0111909 | autosomal dominant thrombophilia due to protein C deficiency | |
| DOID:10159 | osteonecrosis | |
| DOID:10591 | pre-eclampsia | |
| DOID:10772 | thrombotic thrombocytopenic purpura | |
| DOID:11247 | disseminated intravascular coagulation | |
| DOID:14115 | toxic shock syndrome | |
| DOID:2450 | central retinal vein occlusion |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 5624 | HGNC:9451 | HUMAN64633 | ||
| 19123 | 10090_1:00506e | MGI:97771 | MOUSE23485 | |
| 281428 | BOVIN23858 | |||
| 393327 | ZFIN:ZDB-GENE-060824-5 | DANRE28803 | ||
| 396954 | PIGXX08919 | |||
| 459593 | PANTR28606 | |||
| 476104 | CANLF06322 | |||
| 548476 | Xenbase:XB-GENE-973141 | |||
| 699077 | MACMU05799 | |||
| 100009223 | RABIT11583 |
