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fucosyltransferase 5

Summary

Gene Symbol

FUT5

Aliases

FUC-TV
alpha (1,3) fucosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

2527

GGDB ID

gg005

HGNC

4016

mRNA

NM_002034

map

19p13.3

Protein

NP_002025

OMIM

136835

KEGG Gene ID

hsa:2527

PubChem

2527

Alliance of Genome Resources

HGNC:4016

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q11128	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT5 Fucosyltransferase 5 Fucosyltransferase V Galactoside 3-L-fucosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
ceramide metabolic process	IDA	17604274 7721776 9737988
oligosaccharide biosynthetic process	TAS
fucosylation	IBA
protein O-linked glycosylation	IDA	29593094
protein glycosylation	TAS	11698403

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

catabolic process [inference]

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

oligosaccharide metabolic process

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

glycosylation [inference]

fucosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

oligosaccharide metabolic process

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi apparatus	TAS	11698403
Golgi cisterna membrane	IEA
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	IDA	14718375 1740457 9737988
alpha-(1->3)-fucosyltransferase activity	IBA TAS	11698403
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA	14718375 1740457 17604274 29593094 7721776 9737988
fucosyltransferase activity	IDA	17604274 7721776

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity

alpha-(1->3)-fucosyltransferase activity

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Fucosyltransferase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
alpha-(1->3)-fucosyltransferase activity
fucosylation
fucosyltransferase activity
transferase activity

Displaying **all 3** entries
InterPro
Fucosyltransferase, N-terminal
GT10-like, C-terminal domain superfamily
Glycosyl transferase family 10

GlycoGene Database (GGDB)

GGDB ID

gg005

Gene Symbol

FUT5

Reactions

Displaying entries **1 - 5** of 6 in total

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
GDP-Fuc	G32061UE	R	G20009FG	R	17604274
GDP-Fuc	G61459JW	R	G00052MO	R	16484342
GDP-Fuc	G00056MO	R	G39023AU	R	8780523
GDP-Fuc	G84224TW	R	G57548NB	R	8780523
GDP-Fuc	G00055MO	R	G00051MO	R	8780523

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
GDP-Fuc	G32061UE	R	G20009FG	R	17604274
GDP-Fuc	G61459JW	R	G00052MO	R	16484342
GDP-Fuc	G00056MO	R	G39023AU	R	8780523
GDP-Fuc	G40696TO	(CH2)8COOCH3	G00048MO	(CH2)8COOCH3	9079712
GDP-Fuc	G84224TW	R	G57548NB	R	8780523

KEGG BRITE Database

Orthology

K07633

Name

galactoside alpha-1,3-fucosyltransferase 5 [EC:2.4.1.65]

References

1740457

Reactions

Displaying entries **1 - 10** of 11 in total

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KEGG Reaction	Enzyme	Acceptor	Product
R06039	2.4.1.- 2.4.1.152 2.4.1.65	G77285LE	G00851XQ
R06224	2.4.1.- 2.4.1.152 2.4.1.65	G52160KJ	G20180GO
R06025	2.4.1.- 2.4.1.152 2.4.1.65	G58896AZ	G72002FC
R06221	2.4.1.- 2.4.1.152 2.4.1.65	G76439VL	G91560NT
R06075	2.4.1.- 2.4.1.65	G01767JJ	G96401FK
R06095	2.4.1.- 2.4.1.152 2.4.1.65	G13636IT	G89659QV
R06227	2.4.1.- 2.4.1.152 2.4.1.65	G07075ZE	G03564IA
R06230	2.4.1.- 2.4.1.152 2.4.1.65	G84034JH	G65223RT
R06222	2.4.1.- 2.4.1.152 2.4.1.65	G00851XQ	G52160KJ
R06076	2.4.1.- 2.4.1.152 2.4.1.65	G66427ZQ	G07075ZE

Rhea

RHEA:23628

a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

a β-D-galactosyl-(1→3)-[α-L-fucosyl-(1→4)]-N-acetyl-β-D-glucosaminyl derivative + H⁺ + GDP

Enzyme

2.4.1.65

PMID

RHEA:14257

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

a β-D-galactosyl-(1→4)-[α-L-fucosyl-(1→3)]-N-acetyl-β-D-glucosaminyl derivative + H⁺ + GDP

Enzyme

2.4.1.152

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1508	candidiasis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 33 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39653		FB:FBgn0036485
Caenorhabditis elegans	173958		WB:WBGene00006402
Caenorhabditis elegans	174400		WB:WBGene00001505
Caenorhabditis elegans	187342		WB:WBGene00001507
Bos taurus	338077			BOVIN32832
Xenopus tropicalis	447987		Xenbase:XB-GENE-5889327
Canis lupus familiaris	449024			CANLF07980
Pan troglodytes	455628	9598_0:004dd7
Drosophila melanogaster	3355171		FB:FBgn0044872
Monodelphis domestica	100015438			MONDO00980

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements