glutamate-cysteine ligase, catalytic subunit

Summary
Gene Symbol
  • Gclc
Organism
Rattus norvegicus (Norway rat)
NCBI Gene
25283
PubChem
25283
Alliance of Genome Resources
Annotation
Keyword
  • ATP-binding
  • Acetylation
  • Direct protein sequencing
  • Glutathione biosynthesis
  • Ligase
  • Phosphoprotein
  • Reference proteome
Proteins
Displaying all 2 entries
UniProt Protein Name
P19468
  • GCS heavy chain
  • Gamma-ECS
  • Gamma-glutamylcysteine synthetase
A6I1G6
  • Gamma-ECS
  • Gamma-glutamylcysteine synthetase
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
OrthoDB (Group)
Group level
Rodentia
Group Name
glutamate--cysteine ligase catalytic subunit
Functional Category
  • C: Energy production and conversion
  • P: Inorganic ion transport and metabolism
  • Q: Secondary metabolites biosynthesis, transport and catabolism
Alliance of Genome Resources
Expression
Displaying 1 entry
Location References
Disease
Disease Ontology
Displaying all 8 entries
DO ID Disease Name Source
DOID:0111681 glutamate-cysteine ligase deficiency
DOID:1485 cystic fibrosis
DOID:5082 liver cirrhosis
DOID:583 hemolytic anemia
DOID:5844 myocardial infarction
DOID:83 cataract
DOID:9256 colorectal cancer
DOID:9675 pulmonary emphysema

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024