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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
glutamate-cysteine ligase, catalytic subunit
Summary
- Gene Symbol
-
- Gclc
- Organism
- Rattus norvegicus (Norway rat)
Annotation
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of neuron apoptotic process | ||
| negative regulation of hepatic stellate cell activation | ||
| cellular response to insulin stimulus | ||
| response to activity | ||
| glutathione metabolic process |
GO Hierarchy
- response to activity
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| glutamate-cysteine ligase complex | ||
| mitochondrion | ||
| cytosol |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| glutamate-cysteine ligase activity | ||
| protein-containing complex binding | ||
| glutamate binding | ||
| magnesium ion binding | ||
| ADP binding |
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- glutamate--cysteine ligase catalytic subunit
- Functional Category
-
- C: Energy production and conversion
- P: Inorganic ion transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
| Gene Ontology |
|---|
| ATP binding |
| catalytic activity |
| glutamate-cysteine ligase activity |
| glutathione biosynthetic process |
| ligase activity |
| nucleotide binding |
| InterPro |
|---|
| Glutamate-cysteine ligase catalytic subunit |
| Glutamine synthetase/guanido kinase, catalytic domain |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 118903717 | BALMU25901 | |||
| 119809023 | 1047088_0:001285 | |||
| 121466173 | 111838_0:00409f | |||
| 122101558 | 105255_0:004d39 | |||
| 122220033 | PANLE15687 | |||
| 124102304 | 9995_0:00226e | |||
| 124988811 | 30640_0:002787 | |||
| 125352480 | 214514_0:001d25 | |||
| 125393504 | 447135_0:00465c | |||
| 126489965 | 100897_0:000735 |
