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aquaporin 4

Summary

Gene Symbol

Aqp4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25293

PubChem

25293

Alliance of Genome Resources

RGD:2143

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Endosome
Glycoprotein
Palmitate
Phosphoprotein
Porin
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6KLU9
A0A0H2UHZ1
P47863	Mercurial-insensitive water channel WCH4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **31 - 35** of 35 in total

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GO Term	Evidence Code	PMID
cellular response to interleukin-6	IEP	22449442
cellular response to estradiol stimulus	IEP	21471464
cerebrospinal fluid circulation	ISS
cerebrospinal fluid circulation	ISO
cell-cell adhesion	IMP	16325200

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

cell adhesion [inference]

cell-cell adhesion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to cytokine stimulus [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to estradiol stimulus

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal water transport [inference]

renal water absorption

renal absorption [inference]

renal water absorption

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

cerebrospinal fluid circulation

secretion by tissue [inference]

cerebrospinal fluid secretion

multi-multicellular organism process [inference]

female pregnancy

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

intracellular water homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

intracellular water homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to organic cyclic compound [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

response to lipid [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to lipid [inference]

cellular response to estradiol stimulus

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

response to interleukin-1 [inference]

cellular response to interleukin-1

response to interleukin-6 [inference]

cellular response to interleukin-6

cellular response to cytokine stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to cytokine stimulus [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to cytokine stimulus [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to estradiol stimulus

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to estradiol [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to estradiol stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to cytokine stimulus [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to estradiol stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

gas transport [inference]

carbon dioxide transport

fluid transport [inference]

water transport

renal water transport [inference]

renal water absorption

secretion [inference]

body fluid secretion [inference]

cerebrospinal fluid secretion

secretion by tissue [inference]

cerebrospinal fluid secretion

transmembrane transport

organic substance transport [inference]

water transport

renal water transport [inference]

renal water absorption

one-carbon compound transport [inference]

carbon dioxide transport

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of vascular endothelial growth factor production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of vascular endothelial growth factor production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of vascular endothelial growth factor production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cell adhesion molecule production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of vascular endothelial growth factor production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cell adhesion molecule production

regulation of cell adhesion molecule production [inference]

negative regulation of cell adhesion molecule production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of vascular endothelial growth factor production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion [inference]

cerebrospinal fluid secretion

multicellular organismal-level water homeostasis

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
cytoplasm	ISO
plasma membrane	ISO
plasma membrane	IDA	16325200
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

sarcolemma

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

cell junction [inference]

anchoring junction [inference]

cell-cell junction

T-tubule

cell projection

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	21262839
water channel activity	ISO
water channel activity	IDA	21251984 7528931
water channel activity	IBA
water channel activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

passive transmembrane transporter activity [inference]

channel activity

water channel activity

salt transmembrane transporter activity [inference]

water transmembrane transporter activity [inference]

water channel activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aquaporin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
water channel activity

Displaying **all 4** entries
InterPro
Aquaporin transporter
Aquaporin-like
Major intrinsic protein, conserved site
Major intrinsic protein

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
protein-containing complex	PMID:20153404
cell projection membrane	PMID:9875338
basolateral plasma membrane	PMID:12507761 PMID:9875338
T-tubule	PMID:20849844
sarcolemma	PMID:20849844
basal plasma membrane	PMID:9875338

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1824	status epilepticus	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **116** in total

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Species	Gene ID	Orthologous MAtrix
Monodelphis domestica	100010466	MONDO18289
Ornithorhynchus anatinus	100073374	ORNAN24973
Sus scrofa	100126277	PIGXX29906
Taeniopygia guttata	100232616	TAEGU17967
Callithrix jacchus	100409781	CALJA08969
Ailuropoda melanoleuca	100481467	AILME19415
Meleagris gallopavo	100542522	MELGA09014
Anolis carolinensis	100556774	ANOCA05541
Nomascus leucogenys	100595377	NOMLE28937
Loxodonta africana	100676682	LOXAF18533

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements