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neuropeptide Y receptor Y5

Summary

Gene Symbol

Npy5r

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25340

PubChem

25340

Alliance of Genome Resources

RGD:3199

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Neuropeptide
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q63634	NPY-Y5 receptor
A6KFL9	NPY-Y5 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
positive regulation of acute inflammatory response	IMP	12161018
negative regulation of acute inflammatory response to antigenic stimulus	IDA	18805447
outflow tract morphogenesis	ISO
cardiac left ventricle morphogenesis	ISO
G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic signaling via neuropeptide

signal transduction [inference]

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

reproductive process [inference]

ovulation cycle process [inference]

generation of ovulation cycle rhythm

multicellular organismal process [inference]

behavior [inference]

feeding behavior [inference]

eating behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

outflow tract morphogenesis

cardiac chamber morphogenesis [inference]

cardiac ventricle morphogenesis [inference]

cardiac left ventricle morphogenesis

rhythmic process [inference]

ovulation cycle process [inference]

generation of ovulation cycle rhythm

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of immune response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic signaling via neuropeptide

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of amino acid transport [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

regulation of secretion by cell [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of amine transport [inference]

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of amino acid transport [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of acute inflammatory response

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of immune response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of acute inflammatory response

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

regulation of secretion by cell [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
plasma membrane	IBA
membrane	ISO
neuron projection	ISO
neuron projection	IBA
presynapse	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

synapse [inference]

GABA-ergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

presynapse

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
peptide YY receptor activity	ISO
peptide YY receptor activity	IDA	8824284
peptide YY receptor activity	IBA
pancreatic polypeptide receptor activity	ISO
pancreatic polypeptide receptor activity	IDA	8824284

GO Hierarchy

molecular function

binding [inference]

amide binding [inference]

peptide binding [inference]

neuropeptide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity [inference]

neuropeptide Y receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity [inference]

neuropeptide Y receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

neuropeptide Y receptor type 5

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
chemical synaptic transmission
neuropeptide Y receptor activity
neuropeptide binding
neuropeptide signaling pathway
pancreatic polypeptide receptor activity
peptide YY receptor activity

Displaying **all 4** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Neuropeptide Y receptor family
Neuropeptide Y5 receptor

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:1825	childhood absence epilepsy	Alliance of Genome Resources
DOID:2018	hyperinsulinism	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4889	Xenbase:XB-GENE-960863	HUMAN77984
Drosophila melanogaster	18166	FB:FBgn0037408
Mus musculus	18168	Xenbase:XB-GENE-960863	MOUSE58754
Drosophila melanogaster	18169	FB:FBgn0037408
Drosophila melanogaster	19065	FB:FBgn0037408
Xenopus tropicalis	25340	Xenbase:XB-GENE-960863
Drosophila melanogaster	29471	FB:FBgn0037408
Drosophila melanogaster	182921	FB:FBgn0037408
Pan troglodytes	461582		PANTR34736
Macaca mulatta	574150		MACMU37143

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Acknowledgements