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cathepsin C

Summary

Gene Symbol

Ctsc

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25423

PubChem

25423

Alliance of Genome Resources

RGD:2445

Annotation

Keyword

3D-structure
Chloride
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Reference proteome
Signal
Thiol protease
Zymogen

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P80067	Cathepsin C Cathepsin J Dipeptidyl peptidase I Dipeptidyl transferase
A6I5Z1	Cathepsin C Cathepsin J Dipeptidyl peptidase I Dipeptidyl transferase
A6I5Z3
A0A8I5ZZG1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
T cell mediated cytotoxicity	ISO
proteolysis	ISO
proteolysis	TAS	12553666
apoptotic process	IEA
negative regulation of myelination	ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

T cell mediated cytotoxicity

lymphocyte mediated immunity [inference]

T cell mediated immunity [inference]

T cell mediated cytotoxicity

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

T cell mediated immunity [inference]

T cell mediated cytotoxicity

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

cellular process [inference]

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

T cell mediated cytotoxicity

cell death [inference]

programmed cell death [inference]

apoptotic process

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

T cell mediated immunity [inference]

T cell mediated cytotoxicity

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of microglial cell activation [inference]

positive regulation of microglial cell activation

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteolysis involved in protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteolysis involved in protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteolysis involved in protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of myelination

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of inflammatory response [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of neuroinflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of microglial cell activation [inference]

positive regulation of microglial cell activation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of inflammatory response [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of neuroinflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of microglial cell activation [inference]

positive regulation of microglial cell activation

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

regulation of myelination [inference]

negative regulation of myelination

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

negative regulation of cellular process [inference]

negative regulation of myelination

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of microglial cell activation [inference]

positive regulation of microglial cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of microglial cell activation [inference]

positive regulation of microglial cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular space	IBA
nucleoplasm	ISO
nucleoplasm	IEA
cytoplasm	ISO
lysosome	IDA	18307834

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cysteine-type endopeptidase activity	NAS	11788364
cysteine-type endopeptidase activity	IBA
serine-type endopeptidase activity	ISO
cysteine-type peptidase activity	ISO
dipeptidyl-peptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type peptidase activity

cysteine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

exopeptidase activity [inference]

dipeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type peptidase activity

cysteine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

exopeptidase activity [inference]

dipeptidyl-peptidase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

phosphatase binding

ion binding [inference]

anion binding [inference]

chloride ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process

peptidase regulator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

dipeptidyl peptidase 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
cysteine-type endopeptidase activity
dipeptidyl-peptidase activity
hydrolase activity
proteolysis involved in protein catabolic process
proteolysis

Displaying **all 9** entries
InterPro
Cathepsin C exclusion
Cathepsin C, exclusion domain superfamily
Cathepsin C
Cysteine peptidase, asparagine active site
Cysteine peptidase, cysteine active site
Cysteine peptidase, histidine active site
Papain-like cysteine peptidase superfamily
Peptidase C1A, papain C-terminal
Peptidase C1A

Ortholog

Displaying entries **31 - 40** of 80 in total

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Species	Gene ID	Orthologous MAtrix
Gorilla gorilla gorilla	101146804	GORGO01813
Oryzias latipes	101170449	ORYLA03583
Tursiops truncatus	101316165	TURTR03461
Jaculus jaculus	101593504	JACJA09657
Mustela putorius furo	101681849	MUSPF08723
Heterocephalus glaber	101697606	HETGA23399
Ficedula albicollis	101814128	FICAL06747
Chrysemys picta bellii	101935953	CHRPI16842
Macaca fascicularis	102137896	MACFA10055
Capra hircus	102190937	CAPHI18921

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OrthoDB (Group)

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Acknowledgements