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solute carrier family 37 member 4

Summary

Gene Symbol

SLC37A4

Aliases

G6PT
GSD1b
GSD1c
GSD1d
Glucose-6-phosphate exchanger SLC37A4
SPX4
glucose-6-phosphatase transporter
sugar-phosphate exchange protein 4

Organism

Homo sapiens (human)

External Links

NCBI Gene

2542

HGNC

4061

KEGG Gene ID

hsa:2542

PubChem

2542

Alliance of Genome Resources

HGNC:4061

Annotation

Keyword

Alternative splicing
Antiport
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycogen storage disease
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
O43826	Glucose-5-phosphate transporter Glucose-6-phosphate translocase Solute carrier family 37 member 4 Transformation-related gene 19 protein
B4DUH2
A8K0S7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phosphate ion transmembrane transport	IBA IDA	21949678
glucose metabolic process	NAS	9428641
glucose homeostasis
glucose-6-phosphate transport	IBA IDA IMP NAS	10026167 12560945 21949678 33964207 9428641
gluconeogenesis	TAS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

inorganic anion transport [inference]

phosphate ion transport [inference]

phosphate ion transmembrane transport

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

organic substance transport [inference]

organophosphate ester transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

carbohydrate derivative transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	NAS	212064
endoplasmic reticulum membrane	IBA IDA TAS	21949678 33964207
plasma membrane
membrane	HDA NAS	19946888 9428641

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glucose-6-phosphate transmembrane transporter activity	IMP	12560945
glucose 6-phosphate:inorganic phosphate antiporter activity	EXP IBA IDA TAS	18337460 21949678
protein binding	IPI	32296183

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

solute:inorganic anion antiporter activity [inference]

organophosphate:inorganic phosphate antiporter activity [inference]

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

phosphate ion transmembrane transporter activity [inference]

organophosphate:inorganic phosphate antiporter activity [inference]

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

organophosphate ester transmembrane transporter activity [inference]

hexose phosphate transmembrane transporter activity [inference]

glucose-6-phosphate transmembrane transporter activity

glucose 6-phosphate:inorganic phosphate antiporter activity

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

solute:inorganic anion antiporter activity [inference]

organophosphate:inorganic phosphate antiporter activity [inference]

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

hexose phosphate transmembrane transporter activity [inference]

glucose-6-phosphate transmembrane transporter activity

glucose 6-phosphate:inorganic phosphate antiporter activity

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000137700

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K08171

Name

MFS transporter, OPA family, solute carrier family 37 (glycerol-6-phosphate transporter), member 4

References

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:12987	agranulocytosis	DisGeNET DisGeNET
DOID:1312	focal segmental glomerulosclerosis	DisGeNET
DOID:13189	gout	DisGeNET
DOID:1319	brain cancer	DisGeNET
DOID:13579	kwashiorkor	DisGeNET
DOID:1425	pyoureter	DisGeNET
DOID:14557	primary pulmonary hypertension	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1837	diabetic ketoacidosis	DisGeNET DisGeNET
DOID:1920	hyperuricemia	DisGeNET

The Human Phenotype Ontology

Displaying entries **111 - 120** of **135** in total

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HPO ID	HPO Term
HP:0010280	Stomatitis
HP:0010296	Ankyloglossia
HP:0010974	Abnormal myeloid leukocyte morphology
HP:0011069	Supernumerary tooth
HP:0011120	Concave nasal ridge
HP:0011462	Young adult onset
HP:0011858	Reduced factor IX activity
HP:0011889	Bleeding with minor or no trauma
HP:0011890	Prolonged bleeding following procedure
HP:0011900	Hypofibrinogenemia

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:232240	glycogen storage disease Ib
OMIM:619525	congenital disorder of glycosylation, type IIw
ORPHA:79259	glycogen storage disease Ib
OMIM:232220	glycogen storage disease Ib

PubChem Disease

GHR Health Conditions

Glycogen storage disease type I

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Orthologous MAtrix
Vombatus ursinus	114023126	VOMUR13553
Bos indicus x Bos taurus	113905771	BOBOX35478
Microcebus murinus	105876027	MICMU09192
Otolemur garnettii	100960090	OTOGA06095
Takifugu rubripes	101071890	TAKRU03072
Chinchilla lanigera	102022899	CHILA03451
Aotus nancymaae	105729528	AOTNA05806
Saimiri boliviensis boliviensis	101050173	SAIBB06423
Ictidomys tridecemlineatus	101965157	ICTTR09575
Jaculus jaculus	101595377	JACJA19302

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Tools

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Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements