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solute carrier family 37 member 4

Summary

Gene Symbol

SLC37A4

Aliases

G6PT
GSD1b
GSD1c
GSD1d
Glucose-6-phosphate exchanger SLC37A4
SPX4
glucose-6-phosphatase transporter
sugar-phosphate exchange protein 4

Organism

Homo sapiens (human)

External Links

NCBI Gene

2542

HGNC

4061

KEGG Gene ID

hsa:2542

PubChem

2542

Alliance of Genome Resources

HGNC:4061

Annotation

Keyword

Alternative splicing
Antiport
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycogen storage disease
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
O43826	Glucose-5-phosphate transporter Glucose-6-phosphate translocase Solute carrier family 37 member 4 Transformation-related gene 19 protein
B4DUH2
A8K0S7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phosphate ion transmembrane transport	IBA IDA	21949678
glucose metabolic process	NAS	9428641
glucose homeostasis
glucose-6-phosphate transport	IBA IDA IMP NAS	10026167 12560945 21949678 33964207 9428641
gluconeogenesis	TAS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

inorganic anion transport [inference]

phosphate ion transport [inference]

phosphate ion transmembrane transport

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

organic substance transport [inference]

organophosphate ester transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

carbohydrate derivative transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	NAS	212064
endoplasmic reticulum membrane	IBA IDA TAS	21949678 33964207
plasma membrane
membrane	HDA NAS	19946888 9428641

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glucose-6-phosphate transmembrane transporter activity	IMP	12560945
glucose 6-phosphate:inorganic phosphate antiporter activity	EXP IBA IDA TAS	18337460 21949678
protein binding	IPI	32296183

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

solute:inorganic anion antiporter activity [inference]

organophosphate:inorganic phosphate antiporter activity [inference]

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

phosphate ion transmembrane transporter activity [inference]

organophosphate:inorganic phosphate antiporter activity [inference]

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

organophosphate ester transmembrane transporter activity [inference]

hexose phosphate transmembrane transporter activity [inference]

glucose-6-phosphate transmembrane transporter activity

glucose 6-phosphate:inorganic phosphate antiporter activity

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

solute:inorganic anion antiporter activity [inference]

organophosphate:inorganic phosphate antiporter activity [inference]

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

hexose phosphate transmembrane transporter activity [inference]

glucose-6-phosphate transmembrane transporter activity

glucose 6-phosphate:inorganic phosphate antiporter activity

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000137700

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K08171

Name

MFS transporter, OPA family, solute carrier family 37 (glycerol-6-phosphate transporter), member 4

References

Disease

Disease Ontology

Displaying entries **1 - 10** of 93 in total

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DO ID	Disease Name	Source
DOID:0111043	glycogen storage disease IXc	DisGeNET
DOID:0014667	disease of metabolism	DisGeNET
DOID:0050571	congenital disorder of glycosylation type II	Alliance of Genome Resources
DOID:0050590	severe congenital neutropenia	DisGeNET DisGeNET
DOID:0081330	glycogen storage disease Ib	Alliance of Genome Resources
DOID:0081331	glycogen storage disease Ic	Alliance of Genome Resources
DOID:0110741	type 1 diabetes mellitus 2	DisGeNET
DOID:0110742	type 1 diabetes mellitus 3	DisGeNET
DOID:0110743	type 1 diabetes mellitus 4	DisGeNET
DOID:0110744	type 1 diabetes mellitus 5	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of **135** in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000023	Inguinal hernia
HP:0000083	Renal insufficiency
HP:0000093	Proteinuria
HP:0000097	Focal segmental glomerulosclerosis
HP:0000105	Enlarged kidney
HP:0000121	Nephrocalcinosis
HP:0000132	Menorrhagia
HP:0000147	Polycystic ovaries

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:232240	glycogen storage disease Ib
OMIM:619525	congenital disorder of glycosylation, type IIw
ORPHA:79259	glycogen storage disease Ib
OMIM:232220	glycogen storage disease Ib

PubChem Disease

GHR Health Conditions

Glycogen storage disease type I

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **21 - 30** of 90 in total

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Species	Gene ID	Orthologous MAtrix
Sarcophilus harrisii	100916715	SARHA10275
Erinaceus europaeus	103113979	ERIEU04079
Callithrix jacchus	100411680	CALJA04456
Cercocebus atys	105582494	CERAT14935
Macaca fascicularis	101867441	MACFA10538
Macaca mulatta	702269	MACMU08915
Macaca nemestrina	105476388	MACNE14793
Papio anubis	101026632	PAPAN05775
Mandrillus leucophaeus	105528237	MANLE06731
Gorilla gorilla gorilla	101131534	GORGO03951

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GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements