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meiosis specific with OB-fold

Summary

Gene Symbol

MEIOB

Organism

Homo sapiens (human)

External Links

NCBI Gene

254528

PubChem

254528

Alliance of Genome Resources

HGNC:28569

Annotation

Keyword

Alternative splicing
Chromosome
Cytoplasm
DNA-binding
Disease variant
Exonuclease
Meiosis
Nucleus
Premature ovarian failure
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N635

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
resolution of meiotic recombination intermediates	ISS
resolution of meiotic recombination intermediates	IBA
double-strand break repair via homologous recombination	ISS
homologous chromosome pairing at meiosis	ISS
male meiotic nuclear division	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular process [inference]

cell cycle process [inference]

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

meiosis I [inference]

chromosome organization involved in meiotic cell cycle [inference]

homologous chromosome pairing at meiosis

meiotic nuclear division [inference]

meiosis I [inference]

male meiotic nuclear division

male meiosis I

female meiotic nuclear division [inference]

female meiosis I

cellular process involved in reproduction in multicellular organism [inference]

male meiotic nuclear division

male meiosis I

female meiotic nuclear division [inference]

female meiosis I

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle fission [inference]

nuclear division [inference]

meiotic nuclear division [inference]

meiosis I [inference]

male meiotic nuclear division

male meiosis I

female meiotic nuclear division [inference]

female meiosis I

chromosome organization [inference]

chromosome organization involved in meiotic cell cycle [inference]

homologous chromosome pairing at meiosis

reproductive process [inference]

fertilization

cellular process involved in reproduction in multicellular organism [inference]

male meiotic nuclear division

male meiosis I

female meiotic nuclear division [inference]

female meiosis I

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

meiosis I [inference]

chromosome organization involved in meiotic cell cycle [inference]

homologous chromosome pairing at meiosis

meiotic nuclear division [inference]

meiosis I [inference]

male meiotic nuclear division

male meiosis I

female meiotic nuclear division [inference]

female meiosis I

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IMP	35991565
chromosome	IEA
cytoplasm	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chromatin binding	ISS
single-stranded DNA binding	ISS
single-stranded DNA binding	IBA
protein binding	IPI	28514442 33961781
single-stranded DNA 3'-5' DNA exonuclease activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

3'-5' exonuclease activity [inference]

3'-5'-DNA exonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

binding [inference]

protein binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

single-stranded DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

meiosis-specific with OB domain-containing protein

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
resolution of meiotic recombination intermediates
single-stranded DNA 3'-5' DNA exonuclease activity

Displaying 1 entry
InterPro
Nucleic acid-binding, OB-fold

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070177	spermatogenic failure 22	Alliance of Genome Resources
DOID:5426	primary ovarian insufficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 54 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	75178		MOUSE20462
Xenopus tropicalis	254528	Xenbase:XB-GENE-987591
Rattus norvegicus	685099		RATNO01777
Macaca mulatta	703322		MACMU26766
Pan troglodytes	750018		PANTR11442
Monodelphis domestica	100011585		MONDO28508
Equus caballus	100067958		HORSE06941
Taeniopygia guttata	100227967		TAEGU05266
Pongo abelii	100435944		PONAB10402
Ailuropoda melanoleuca	100469338		AILME11844