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MIRAGE
insulin receptor substrate 1
Summary
- Gene Symbol
-
- Irs1
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- 3D-structure
- Direct protein sequencing
- Phosphoprotein
- Reference proteome
- Repeat
- S-nitrosylation
- Transducer
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P35570 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of mesenchymal cell proliferation | ||
| insulin receptor signaling pathway | ||
| insulin receptor signaling pathway | ||
| insulin receptor signaling pathway | ||
| insulin receptor signaling pathway |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of secretion by cell [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| nucleus | ||
| nucleoplasm | ||
| nucleoplasm | ||
| cytoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphotyrosine residue binding | ||
| phosphotyrosine residue binding | ||
| transmembrane receptor protein tyrosine kinase adaptor activity | ||
| transmembrane receptor protein tyrosine kinase adaptor activity | ||
| protein kinase C binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Insulin receptor substrate
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| insulin receptor binding |
| insulin receptor signaling pathway |
| phosphatidylinositol 3-kinase binding |
| InterPro |
|---|
| IRS-type PTB domain |
| Insulin receptor substrate |
| PH-like domain superfamily |
| Pleckstrin homology domain |
Disease
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 105473988 | MACNE18905 | ||
| 105543176 | MANLE15877 | ||
| 105586974 | CERAT22274 | ||
| 105712891 | AOTNA03011 | ||
| 105759506 | TAEGU30401 | ||
| 105982400 | DIPOR00357 | ||
| 106827854 | EQUAS24775 | ||
| 107582225 | SINGR27410 | ||
| 108278298 | ICTPU10291 | ||
| 108440437 | PYGNA25104 |
