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solute carrier family 18 member A2

Summary

Gene Symbol

Slc18a2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25549

PubChem

25549

Alliance of Genome Resources

RGD:3694

Annotation

Keyword

Cell projection
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Neurotransmitter transport
Phosphoprotein
Reference proteome
Synapse
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0G2JSJ6
A6JI82
Q01827	Monoamine transporter Solute carrier family 18 member 2 Vesicular amine transporter 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **36 - 40** of 42 in total

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GO Term	Evidence Code	PMID
histamine uptake	IEA
cellular response to ammonium ion	IEP	20534840
cellular response to xenobiotic stimulus	IMP	20007701
neurotransmitter loading into synaptic vesicle	ISO
neurotransmitter loading into synaptic vesicle	IEA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endocytic recycling

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

endocytic recycling

localization within membrane [inference]

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

exocytic process [inference]

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

dopamine secretion [inference]

somato-dendritic dopamine secretion

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide hormone secretion [inference]

insulin secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

multicellular organismal process [inference]

behavior [inference]

locomotory behavior

post-embryonic development

response to stimulus [inference]

response to stress [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to starvation

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to chemical [inference]

response to xenobiotic stimulus

cellular response to xenobiotic stimulus

response to toxic substance

response to herbicide

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to alkaloid [inference]

response to cocaine

response to organic cyclic compound [inference]

response to cocaine

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to alcohol [inference]

response to corticosterone

response to ketone [inference]

response to corticosterone

response to inorganic substance [inference]

response to metal ion

response to zinc ion

response to ammonium ion [inference]

cellular response to ammonium ion

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to alkaloid [inference]

response to cocaine

response to ammonium ion [inference]

cellular response to ammonium ion

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

response to oxygen-containing compound [inference]

response to cocaine

response to alcohol [inference]

response to corticosterone

response to ketone [inference]

response to corticosterone

response to salt [inference]

response to cocaine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

neurotransmitter transport

neurotransmitter uptake [inference]

histamine uptake

neurotransmitter reuptake [inference]

serotonin uptake

neurotransmitter loading into synaptic vesicle

aminergic neurotransmitter loading into synaptic vesicle

hormone transport [inference]

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide hormone secretion [inference]

insulin secretion

vesicle-mediated transport [inference]

endosomal transport [inference]

endocytic recycling

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

xenobiotic transport

secretion [inference]

histamine secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

dopamine secretion [inference]

somato-dendritic dopamine secretion

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide hormone secretion [inference]

insulin secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

intracellular transport [inference]

endosomal transport [inference]

endocytic recycling

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

amine transport [inference]

aminergic neurotransmitter loading into synaptic vesicle

monoamine transport

serotonin transport [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

serotonin uptake

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

organic hydroxy compound transport [inference]

serotonin transport [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

serotonin uptake

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

histamine transport [inference]

histamine secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine uptake

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

amine transport [inference]

aminergic neurotransmitter loading into synaptic vesicle

monoamine transport

serotonin transport [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

serotonin uptake

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

histamine transport [inference]

histamine secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine uptake

import into cell [inference]

neurotransmitter uptake [inference]

histamine uptake

neurotransmitter reuptake [inference]

serotonin uptake

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

dopamine secretion [inference]

somato-dendritic dopamine secretion

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide hormone secretion [inference]

insulin secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport [inference]

endocytic recycling

neurotransmitter loading into synaptic vesicle

aminergic neurotransmitter loading into synaptic vesicle

neurotransmitter reuptake [inference]

serotonin uptake

somato-dendritic dopamine secretion

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

endocytic recycling

localization within membrane [inference]

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of neurotransmitter transport

regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter transport

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of neurotransmitter transport

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide hormone secretion [inference]

insulin secretion

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
centrosome	ISO
centrosome	IEA
synaptic vesicle	IDA	19903816 7568015
axon	IDA	16301178
dendrite	IDA	16301178

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

dense core granule membrane [inference]

neuronal dense core vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

dense core granule membrane [inference]

neuronal dense core vesicle membrane

cell junction [inference]

synapse [inference]

dopaminergic synapse

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

neuronal dense core vesicle

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

neuronal dense core vesicle

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

neuronal dense core vesicle

exocytic vesicle [inference]

synaptic vesicle

cell body

neuronal cell body

neuron projection terminus [inference]

axon terminus

presynapse [inference]

postsynapse

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
amine transmembrane transporter activity	IDA	1505023
serotonin:sodium:chloride symporter activity	IBA
monoamine:proton antiporter activity	ISO
monoamine:proton antiporter activity	IDA	25355561 8125935 8860238
monoamine:proton antiporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

amine transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

monoamine:proton antiporter activity

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoamine:proton antiporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

monoamine:proton antiporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

active transmembrane transporter activity [inference]

monoamine transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

antiporter activity [inference]

monoamine:proton antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoamine:proton antiporter activity

xenobiotic transmembrane transporter activity

organic hydroxy compound transmembrane transporter activity [inference]

serotonin:sodium:chloride symporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

heterocyclic compound binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator superfamily

Alliance of Genome Resources

Expression

Displaying **all 8** entries
Location	References
cell body	PMID:18973576
terminal bouton	PMID:20534840
dense core granule	PMID:7568015
cell projection	PMID:21342027
neuronal cell body	PMID:19457116
synaptic vesicle membrane	PMID:19038779
synaptic vesicle	PMID:19903816 PMID:7568015
axon terminus	PMID:18973576

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 82 in total

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Species	Gene ID	Orthologous MAtrix
Ovis aries	101104796	SHEEP11643
Gorilla gorilla gorilla	101132348	GORGO01310
Tursiops truncatus	101331879	TURTR12021
Octodon degus	101575757	OCTDE03088
Jaculus jaculus	101602116	JACJA10929
Mustela putorius furo	101671502	MUSPF13882
Ficedula albicollis	101816900	FICAL06846
Chrysemys picta bellii	101932022	CHRPI36299
Chinchilla lanigera	102028670	CHILA09278
Macaca fascicularis	102119311	MACFA43490

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements