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proprotein convertase subtilisin/kexin type 9

Summary

Gene Symbol

PCSK9

Organism

Homo sapiens (human)

External Links

NCBI Gene

255738

PubChem

255738

Alliance of Genome Resources

HGNC:20001

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Autocatalytic cleavage
Calcium
Cholesterol metabolism
Cytoplasm
Direct protein sequencing
Disease variant
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Phosphoprotein
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NBP7	Neural apoptosis-regulated convertase 1 Proprotein convertase 9 Subtilisin/kexin-like protease PC9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
kidney development	ISS	12552133
liver development	ISS	12552133
negative regulation of receptor recycling	IDA	17452316 22848640
negative regulation of receptor internalization	IDA	18799458
positive regulation of receptor internalization	IDA	17328821

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

lipoprotein metabolic process

protein maturation [inference]

protein processing [inference]

protein autoprocessing

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

catabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

cellular catabolic process [inference]

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

lipoprotein metabolic process

protein maturation [inference]

protein processing [inference]

protein autoprocessing

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

lipoprotein metabolic process

protein maturation [inference]

protein processing [inference]

protein autoprocessing

receptor metabolic process [inference]

low-density lipoprotein receptor particle metabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

lipoprotein metabolic process

protein maturation [inference]

protein processing [inference]

protein autoprocessing

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

cellular catabolic process [inference]

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

cellular developmental process [inference]

cell differentiation [inference]

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development

gland development [inference]

liver development

cellular developmental process [inference]

cell differentiation [inference]

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling [inference]

negative regulation of receptor recycling

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of signaling [inference]

regulation of receptor recycling [inference]

negative regulation of receptor recycling

regulation of signal transduction [inference]

regulation of signaling receptor activity

negative regulation of signaling [inference]

negative regulation of receptor recycling

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cholesterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of receptor-mediated endocytosis involved in cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

regulation of receptor-mediated endocytosis involved in cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of receptor-mediated endocytosis involved in cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cholesterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

negative regulation of signaling [inference]

negative regulation of receptor recycling

negative regulation of cellular process [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

regulation of neuron apoptotic process

positive regulation of neuron apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of cellular process [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

regulation of receptor-mediated endocytosis involved in cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of receptor-mediated endocytosis involved in cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

regulation of receptor-mediated endocytosis involved in cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

regulation of low-density lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

regulation of molecular function [inference]

regulation of signaling receptor activity

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of molecular function [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding [inference]

negative regulation of low-density lipoprotein particle receptor binding

negative regulation of low-density lipoprotein receptor activity

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding [inference]

negative regulation of low-density lipoprotein particle receptor binding

regulation of receptor binding [inference]

negative regulation of receptor binding [inference]

negative regulation of low-density lipoprotein particle receptor binding

regulation of low-density lipoprotein particle receptor binding [inference]

negative regulation of low-density lipoprotein particle receptor binding

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding [inference]

negative regulation of low-density lipoprotein particle receptor binding

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	12552133 16912035 17080197
extracellular space	IBA
cytoplasm	IDA	22580899
lysosome	IDA	17461796 18039658

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

endolysosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endolysosome membrane

endosome membrane [inference]

endolysosome membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of external side of plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674
serine-type endopeptidase activity	IDA	12552133
serine-type endopeptidase activity	IBA
protein binding	IPI	17461796 18250299 18753623 18799458 22081141 22493497 22580899 22848640 25613181
sodium channel inhibitor activity	IDA	22493497

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

apolipoprotein receptor binding

lipoprotein particle receptor binding [inference]

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor inhibitor activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

ion channel regulator activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

sodium channel regulator activity [inference]

sodium channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protease

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hydrolase activity
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 6** entries
InterPro
Peptidase S8 propeptide/proteinase inhibitor I9 superfamily
Peptidase S8 propeptide/proteinase inhibitor I9
Peptidase S8, subtilisin, Ser-active site
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:13810	familial hypercholesterolemia	Alliance of Genome Resources
DOID:1390	hypobetalipoproteinemia	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 56 in total

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Species	Gene ID	Orthologous MAtrix
Pongo abelii	100457996	PONAB17859
Meleagris gallopavo	100544916	MELGA02462
Anolis carolinensis	100564252	ANOCA06096
Nomascus leucogenys	100580053	NOMLE30670
Loxodonta africana	100661542	LOXAF13556
Oreochromis niloticus	100710647	ORENI45627
Otolemur garnettii	100948210	OTOGA09236
Papio anubis	101003198	PAPAN17880
Saimiri boliviensis boliviensis	101049523	SAIBB02942
Takifugu rubripes	101078715	TAKRU26590

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements